Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research.
Emotional and Motivational Pain Processing: Current State of Knowledge and Perspectives in Translational Research.
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DOI：
10.1155/2018/5457870
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发表时间：
2018
影响因子：
2.9
通讯作者：
Van Damme S
中科院分区：
文献类型：
--
作者：
Becker S;Navratilova E;Nees F;Van Damme S
疼痛消除恐惧和焦虑，促进逃避，回避和适应行为，这是生存所必需的。当疼痛持续时，动机优先级和注意力转移到疼痛相关的信息。这种转变往往会导致功能受损，导致适应不良的疼痛相关的恐惧和焦虑以及逃避和回避行为。对慢性疼痛患者的神经影像学研究已经证实，大脑活动，特别是皮质和中脑边缘区域的活动，与对照组受试者在急性疼痛期间观察到的活动不同。在这篇综述中，我们讨论了可能与慢性疼痛的转变相关的心理生理和神经因素。我们回顾了人类研究中有关情感和动机性疼痛处理的神经回路以及这些回路在慢性疼痛条件下如何改变的信息。然后，我们强调了动物研究的发现，这些发现可以增加我们对大脑情绪激励疼痛处理的分子和细胞机制的了解。最后，我们将讨论如何将人类和动物研究的结果转化为可能有助于加速发现治疗方法。
Pain elicits fear and anxiety and promotes escape, avoidance, and adaptive behaviors that are essential for survival. When pain persists, motivational priority and attention shift to pain-related information. Such a shift often results in impaired functionality, leading to maladaptive pain-related fear and anxiety and escape and avoidance behaviors. Neuroimaging studies in chronic pain patients have established that brain activity, especially in cortical and mesolimbic regions, is different from activity observed during acute pain in control subjects. In this review, we discuss the psychophysiological and neuronal factors that may be associated with the transition to chronic pain. We review information from human studies on neural circuits involved in emotional and motivational pain processing and how these circuits are altered in chronic pain conditions. We then highlight findings from animal research that can increase our understanding of the molecular and cellular mechanisms underlying emotional-motivational pain processing in the brain. Finally, we discuss how translational approaches incorporating results from both human and animal investigations may aid in accelerating the discovery of therapies.
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影响因子：
16.2
作者：
Baliki, Marwan N.;Geha, Paul Y.;Fields, Howard L.;Apkarian, A. Vania
通讯作者：
Apkarian, A. Vania
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Apkarian AV
影响因子：
16.2
作者：
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