Stress evaluation in adult patients with atopic dermatitis using salivary cortisol.
Stress evaluation in adult patients with atopic dermatitis using salivary cortisol.
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DOI：
10.1155/2013/138027
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发表时间：
2013
影响因子：
--
通讯作者：
Shimizu T
中科院分区：
文献类型：
--
作者：
Mizawa M;Yamaguchi M;Ueda C;Makino T;Shimizu T
特应性皮炎（AD）的症状常因压力而加重，AD也会因社会孤立和歧视而导致心理压力。唾液皮质醇水平反映心理应激，是评估慢性应激的良好指标。本研究测定了30例AD患者唾液皮质醇水平，并与42例健康对照者进行了比较。AD患者还使用特应性皮炎评分（SCORAD）指数评估了一般疾病严重程度。通过实验室检查测定血清TARC、总IgE、乳酸脱氢酶（LDH）水平和外周血嗜酸性粒细胞计数。Skindex-16被用作皮肤疾病特异性生活质量测量工具。结果表明，AD患者唾液皮质醇水平显著高于健康人（P < 0.01）。唾液皮质醇水平与SCORAD指数呈显著相关（r = 0.42，P < 0.05），血清TARC和LDH水平与SCORAD指数呈正相关。然而，唾液皮质醇水平和Skindex-16之间没有观察到统计学显著相关性。这些结果表明，唾液皮质醇水平因此是一个有用的生物标志物，以评估在AD患者的压力。
The symptoms of atopic dermatitis (AD) are often aggravated by stress, and AD can also lead to psychological stress due to social isolation and discrimination. The salivary cortisol level reflects psychological stress, and it is a good index to assess chronic stress. In this study, we measured the salivary cortisol levels in patients with AD (n = 30) and compared them with those of healthy control subjects (n = 42). AD patients were also evaluated for general disease severity using the Scoring Atopic Dermatitis (SCORAD) index. The serum levels of TARC, total IgE, and lactate dehydrogenase (LDH) and peripheral blood eosinophil counts were measured by laboratory tests. The Skindex-16 was used as a skin disease-specific, quality of life measure, instrument. The results showed that the saliva cortisol level was significantly higher in AD patients compared to healthy subjects (P < 0.01). The salivary cortisol level was significantly correlated with the SCORAD index (r = 0.42, P < 0.05) while the serum TARC and LDH levels were positively correlated with the SCORAD index. However, no statistically significant correlations were observed between the salivary cortisol level and Skindex-16. These results suggest that the saliva cortisol level is therefore a useful biomarker to evaluate the stress in AD patients.
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影响因子：
3.3
作者：
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影响因子：
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14.2
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