Oxidative Balance Score during Pregnancy Is Associated with Oxidative Stress in the CANDLE Study.
Oxidative Balance Score during Pregnancy Is Associated with Oxidative Stress in the CANDLE Study.
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作者：
本研究的目的是利用从1322名孕中期妇女收集的饮食和生活方式信息，在影响儿童早期神经认知发育和学习的条件研究中计算氧化平衡分数(OBS)。使用食物频率问卷(FFQ)中的营养信息、生活方式测量以及血浆叶酸和维生素D水平来计算能量调整的OBS。使用最小绝对收缩和选择算子方法，从FFQ中选择了91种食物，它们可以解释OBS中82%的方差，十字花科蔬菜、柑橘类水果、果汁和咖啡是最高的抗氧化剂预测因子，红肉和酒精是最高的促氧化剂贡献者。尿F2-异前列腺素是氧化应激的客观指标，随着氧化应激五分位数的增加呈阶梯式下降(趋势p=0.0003)，提示OBS作为氧化应激的指标可能有用。OBS与健康饮食指数呈中度相关(相关系数=0.6076)，表明它提供了健康饮食的独特衡量标准。总之，OBS可作为尿中F2-异前列腺素的有效反映指标，并可作为提供干预研究信息的流行病学工具，以最大限度地减少孕期氧化应激。
The objective of this study was to calculate an oxidative balance score (OBS) utilizing diet and lifestyle information collected from 1322 women during the second trimester of pregnancy in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study. An energy-adjusted OBS was calculated using nutrient information from a Food Frequency Questionnaire (FFQ), lifestyle measures, and plasma folate and vitamin D levels. Using the least absolute shrinkage and selection operator method, 91 food items from the FFQ were selected and they accounted for 82% of the variance in the OBS, with cruciferous vegetables, citrus fruits, fruit juice, and coffee being among the highest anti-oxidant predictors, and red meats and alcohol among the highest pro-oxidant contributors. Urinary F2-isoprostane, an objective indicator of oxidative stress, was lower with increasing OBS quintiles in a stairstep manner (p for trend = 0.0003), suggesting the possible utility of the OBS as an indicator of oxidative stress. The OBS was moderately correlated with the Healthy Eating Index (correlation coefficient = 0.6076), suggesting it provides a distinct measure of a healthy diet. In conclusion, the OBS may serve as a valid reflective indicator of urinary F2-isoprostanes and an epidemiological tool to inform intervention studies, in order to minimize oxidative stress during pregnancy.
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影响因子：
4.8
作者：
Kirkpatrick SI;Reedy J;Krebs-Smith SM;Pannucci TE;Subar AF;Wilson MM;Lerman JL;Tooze JA
通讯作者：
Tooze JA
DOI：
10.1155/2017/3674371
发表时间：
2017
期刊：
Cardiovascular psychiatry and neurology
影响因子：
--
作者：
Mazereeuw G;Herrmann N;Andreazza AC;Scola G;Ma DWL;Oh PI;Lanctôt KL
通讯作者：
Lanctôt KL
影响因子：
11.4
作者：
Ivanova D;Zhelev Z;Getsov P;Nikolova B;Aoki I;Higashi T;Bakalova R
通讯作者：
Bakalova R
影响因子：
4.8
作者：
Guenther, Patricia M.;Casavale, Kellie O.;Reedy, Jill;Kirkpatrick, Sharon I.;Hiza, Hazel A. B.;Kuczynski, Kevin J.;Kahle, Lisa L.;Krebs-Smith, Susan M.
通讯作者：
Krebs-Smith, Susan M.
影响因子：
3.9
作者：
COASSIN, M;URSINI, F;BINDOLI, A
通讯作者：
BINDOLI, A