Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice.
Samsoeum water extract attenuates allergic airway inflammation via modulation of Th1/Th2 cytokines and decrease of iNOS expression in asthmatic mice.
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DOI：
10.1186/s12906-015-0561-3
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发表时间：
2015-03-10
影响因子：
--
通讯作者：
Lee MY
中科院分区：
文献类型：
--
作者：
Jeon WY;Shin IS;Shin HK;Lee MY
三水长期以来在韩国和其他亚洲国家被用作治疗各种疾病的传统药物。在本研究中，我们使用体内卵清蛋白 (OVA) 诱导的哮喘模型研究了草药 Samsoeum 水提取物 (SSEW) 的抗哮喘作用。雌性 BALB/c 小鼠通过腹腔注射 OVA 致敏，随后用雾化 OVA 进行攻击。检测支气管肺泡灌洗液（BALF）中炎性细胞的数量、Th1/Th2细胞因子和趋化因子的产生、肺组织的组织学变化、肺组织中炎性细胞的浸润和杯状细胞的增生情况、BALF和血浆中免疫球蛋白E（IgE）的水平以及诱导型一氧化氮合酶的表达情况。 (iNOS) 存在于肺组织中。我们的研究结果表明，SSEW 减少了 BALF 中炎症细胞（特别是嗜酸性粒细胞和中性粒细胞）的积累，并调节 Th1/Th2 细胞因子和趋化因子产生的平衡。此外，SSEW还能抑制BALF和血浆中IgE的水平，抑制肺组织中炎症细胞的浸润、杯状细胞的增生以及iNOS的表达。总的来说，这些结果表明，由于其抗炎和抗哮喘特性，SSEW 可能有助于减少过敏性哮喘治疗中的气道炎症。
Samsoeum has long been used in Korea and other Asian countries as a traditional medicine to treat various diseases. In the present study, we investigated the antiasthma effect of the herbal medicine Samsoeum water extract (SSEW) using an in vivo ovalbumin (OVA)-induced asthmatic model. Female BALB/c mice were sensitized by an intraperitoneal injection of OVA and subsequently challenged with nebulized OVA. We investigated the number of inflammatory cells, the production of Th1/Th2 cytokines and chemokine in bronchoalveolar lavage fluid (BALF), histological changes in lung tissue, the infiltration of inflammatory cells and hyperplasia of goblet cells in lung tissue, the levels of immunoglobulin E (IgE) in BALF and plasma, and the expression of inducible nitric oxide synthase (iNOS) in lung tissue. Our findings indicated that SSEW decreased the accumulation of inflammatory cells (particularly, eosinophil and neutrophil) and regulated the balance in the production of Th1/Th2 cytokines and chemokine in BALF. Moreover, SSEW suppressed the level of IgE in BALF and plasma, and inhibited the infiltration of inflammatory cells, hyperplasia of goblet cells, and the expression of iNOS in lung tissue. Collectively, these results suggest that, because of its anti-inflammatory and antiasthma properties, SSEW may be useful in reducing airway inflammation in the treatment of allergic asthma.
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影响因子：
7.2
作者：
Lee, Mee-Young;Lee, Jin-Ah;Shin, Hyeun-Kyoo
通讯作者：
Shin, Hyeun-Kyoo
影响因子：
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作者：
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Ma, Shiping
影响因子：
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作者：
Kay, AB
通讯作者：
Kay, AB
影响因子：
10
作者：
Islam, Talat;Breton, Carrie;Gilliland, Frank D.
通讯作者：
Gilliland, Frank D.
影响因子：
--
作者：
Lee MY;Shin IS;Lim HS;Shin HK
通讯作者：
Shin HK