Elastometry of clot phantoms via magnetomotive ultrasound-based resonant acoustic spectroscopy.
Elastometry of clot phantoms via magnetomotive ultrasound-based resonant acoustic spectroscopy.
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DOI：
10.1088/1361-6560/ac7ea5
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发表时间：
2022-07-21
影响因子：
3.5
通讯作者：
中科院分区：
文献类型：
--
作者：
一种基于超声的系统，能够对暗视野血栓成像并进行定量弹性测量，可以实现快速且具有成本效益的血栓诊断、分期和治疗监测。本研究探讨了一种对比度增强的方法来测量的杨氏模量的血栓模仿幻影。磁动超声（MMUS）已显示出通过向磁性纳米颗粒（MNP）造影剂施加时间调制力并测量所产生的组织位移来向血栓提供特定造影剂的前景。然而，定量弹性测量尚未在MMUS中得到证实，这主要是由于测量施加的磁力和MNP密度固有的困难。为了避免这些问题，在这项工作中，磁动共振声学光谱（MRAS）首次在超声。明胶血栓模仿幻影的共振频率同意在一个标准偏差与有限元模拟范围内的幻影尺寸和杨氏模量小于16%的误差。然后，在概念验证研究中，使用MRAS测量三个幻影的杨氏模量，并与独立的压缩测试结果一致。MRAS结果足够精确，可区分具有临床相关杨氏模量的血栓幻影。这些结果表明，MRAS具有血栓分期的潜力。
An ultrasound-based system capable of both imaging thrombi against a dark field and performing quantitative elastometry could allow for fast and cost-effective thrombosis diagnosis, staging, and treatment monitoring. This study investigates a contrast-enhanced approach for measuring the Young’s moduli of thrombus-mimicking phantoms. Magnetomotive ultrasound (MMUS) has shown promise for lending specific contrast to thrombi by applying a temporally modulated force to magnetic nanoparticle (MNP) contrast agents and measuring resulting tissue displacements. However, quantitative elastometry has not yet been demonstrated in MMUS, largely due to difficulties inherent in measuring applied magnetic forces and MNP densities. To avoid these issues, in this work magnetomotive resonant acoustic spectroscopy (MRAS) is demonstrated for the first time in ultrasound. The resonance frequencies of gelatin thrombus-mimicking phantoms are shown to agree within one standard deviation with finite element simulations over a range of phantom sizes and Young’s moduli with less than 16% error. Then, in a proof-of-concept study, the Young’s moduli of three phantoms are measured using MRAS and are shown to agree with independent compression testing results. The MRAS results were sufficiently precise to differentiate between thrombus phantoms with clinically relevant Young’s moduli. These findings demonstrate that MRAS has potential for thrombus staging.
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