Simulating the nasal cycle with computational fluid dynamics.
Simulating the nasal cycle with computational fluid dynamics.
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DOI：
10.1177/0194599814559385
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发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Rhee JS
中科院分区：
文献类型：
--
作者：
Patel RG;Garcia GJ;Frank-Ito DO;Kimbell JS;Rhee JS
(1)在比较术前和术后鼻通畅的客观测量时，开发一种方法来考虑鼻循环的混杂效应。(2)通过报告计算流体动力学（CFD）模型得出的客观测量结果来说明该方法，该模型涵盖了两个受试者与鼻循环相关的全范围粘膜充血。回顾性学术三级医疗中心。我们回顾了24例鼻气道阻塞患者的队列，以选择术前和术后计算机断层扫描（CT）中粘膜充盈互惠变化最大的两例患者。根据术前和术后CT扫描建立三维解剖模型。通过逐渐改变下鼻甲、中鼻甲和鼻中隔肿胀体的厚度，建立鼻循环模型。采用CFD模拟气流，计算鼻腔阻力和平均热流密度。在考虑鼻循环之前，患者A在术后右腔出现了矛盾的鼻塞恶化。考虑到鼻循环后，患者A术后的客观测量有了小的改善。考虑到鼻循环后，患者B的手术效果也有所不同。通过模拟鼻循环和比较类似充血性状态下的模型，可以将鼻通畅的手术改变与鼻循环相关的生理变化区分开来。这种能力可以更精确地比较术前和术后的客观测量，并可能更准确地进行虚拟手术计划。
(1) Develop a method to account for the confounding effect of the nasal cycle when comparing pre- and post-surgery objective measures of nasal patency. (2) Illustrate this method by reporting objective measures derived from computational fluid dynamics (CFD) models spanning the full range of mucosal engorgement associated with the nasal cycle in two subjects. Retrospective Academic tertiary medical center. A cohort of 24 nasal airway obstruction patients was reviewed to select the two patients with the greatest reciprocal change in mucosal engorgement between pre- and post-surgery computed tomography (CT) scans. Three-dimensional anatomic models were created based on the pre- and post-operative CT scans. Nasal cycling models were also created by gradually changing the thickness of the inferior turbinate, middle turbinate, and septal swell body. CFD was used to simulate airflow and to calculate nasal resistance and average heat flux. Before accounting for the nasal cycle, Patient A appeared to have a paradoxical worsening nasal obstruction in the right cavity postoperatively. After accounting for the nasal cycle, Patient A had small improvements in objective measures postoperatively. The magnitude of the surgical effect also differed in Patient B after accounting for the nasal cycle. By simulating the nasal cycle and comparing models in similar congestive states, surgical changes in nasal patency can be distinguished from physiological changes associated with the nasal cycle. This ability can lead to more precise comparisons of pre and post-surgery objective measures and potentially more accurate virtual surgery planning.
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影响因子：
1.4
作者：
BROMS, P;JONSON, B;MALM, L
通讯作者：
MALM, L
DOI：
10.1177/0194599813509776
发表时间：
2014-01
期刊：
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
影响因子：
--
作者：
Sullivan CD;Garcia GJ;Frank-Ito DO;Kimbell JS;Rhee JS
通讯作者：
Rhee JS
影响因子：
2.6
作者：
Rohrmeier, Christian;Schittek, Silke;Kuehnel, Thomas S.
通讯作者：
Kuehnel, Thomas S.
影响因子：
1.4
作者：
KNIGHT, LC;ECCLES, R;REILLY, M
通讯作者：
REILLY, M
影响因子：
2.1
作者：
JESSEN, M;IVARSSON, A;MALM, L
通讯作者：
MALM, L