Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis.
Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis.
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肿瘤浸润淋巴细胞在胃癌中的预后作用：荟萃分析
DOI：
10.18632/oncotarget.18065
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发表时间：
2017-08-22
期刊：
影响因子：
--
通讯作者：
Jiang J
中科院分区：
文献类型：
--
作者：
Zheng X;Song X;Shao Y;Xu B;Chen L;Zhou Q;Hu W;Zhang D;Wu C;Tao M;Zhu Y;Jiang J
背景在胃癌患者中，肿瘤浸润淋巴细胞（TILs）的预后价值仍存在争议。进行荟萃分析以评价TIL在胃癌中的预后价值。材料与方法我们从PubMed、Embase和科克伦图书馆中检索相关研究，以评估TIL对胃癌患者的预后影响。使用固定效应模型或随机效应模型估计总生存期（OS）和无病生存期（DFS）的合并风险比（HR），这取决于异质性。结果共纳入31个观察性研究，包括4,185例患者。对于TIL亚群，CD 8+、FOXP 3+、CD 3+、CD 57+、CD 20+、CD 45 RO+、颗粒酶B+和T-bet+淋巴细胞的数量与生存率的改善显著相关此外，肿瘤内室（IT）中CD 3 + TILs的数量是最重要的预后指标（合并HR = 0.52; 95% CI = 0.43-0.63; P < 0.001）。然而，CD 4 + TILs与患者的生存率无统计学相关性。FOXP 3 + TIL显示双向预后作用，其在IT中具有积极作用（合并HR = 1.57; 95%CI = 1.04-2.37; P = 0.033），在肿瘤外室（ET）中具有消极作用（合并HR = 0.76; 95%CI = 0.60-0.96; P = 0.022）。结论胃癌组织中TIL的某些亚群可作为胃癌预后的生物学指标。需要高质量的随机对照试验来决定这些TIL是否可以作为胃癌免疫治疗的靶点。
Background In patients with gastric cancer, the prognostic value of tumor-infiltrating lymphocytes (TILs) is still controversial. A meta-analysis was performed to evaluate the prognostic value of TILs in gastric cancer. Materials and methods We identify studies from PubMed, Embase and the Cochrane Library to assess the prognostic effect of TILs in patients with gastric cancer. Fixed-effects models or random-effects models were used estimate the pooled hazard ratios (HRs) for overall survival (OS) and disease-free survival (DFS), which depend on the heterogeneity. Results A total of 31 observational studies including 4,185 patients were enrolled. For TILs subsets, the amount of CD8+, FOXP3+, CD3+, CD57+, CD20+, CD45RO+, Granzyme B+ and T-bet+ lymphocytes was significantly associated with improved survival (P < 0.05); moreover, the amount of CD3+ TILs in intra-tumoral compartment (IT) was the most significant prognostic marker (pooled HR = 0.52; 95% CI = 0.43–0.63; P < 0.001). However, CD4+ TILs was not statistically associated with patients’ survival. FOXP3+ TILs showed bidirectional prognostic roles which had positive effect in IT (pooled HR = 1.57; 95% CI = 1.04–2.37; P = 0.033) and negative effect in extra-tumoral compartment (ET) (pooled HR = 0.76; 95% CI = 0.60–0.96; P = 0.022). Conclusions This meta-analysis suggests that some TIL subsets could serve as prognostic biomarkers in gastric cancer. High-quality randomized controlled trials are needed to decide if these TILs could serve as targets for immunotherapy in gastric cancer.
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DOI：
10.1007/s12032-012-0442-2
发表时间：
2013-03
期刊：
Medical oncology (Northwood, London, England)
影响因子：
--
作者：
Dong J;Li J;Liu SM;Feng XY;Chen S;Chen YB;Zhang XS
通讯作者：
Zhang XS
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
3.7
作者：
Hyakudomi, Miki;Matsubara, Takeshi;Tanaka, Tsuneo
通讯作者：
Tanaka, Tsuneo
影响因子：
9.2
作者：
Chen JG;Xia JC;Liang XT;Pan K;Wang W;Lv L;Zhao JJ;Wang QJ;Li YQ;Chen SP;He J;Huang LX;Ke ML;Chen YB;Ma HQ;Zeng ZW;Zhou ZW;Chang AE;Li Q
通讯作者：
Li Q
影响因子：
4.3
作者：
Chang, Wen-Jun;Du, Yan;Cao, Guang-Wen
通讯作者：
Cao, Guang-Wen