Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients.
Early Humoral Response Correlates with Disease Severity and Outcomes in COVID-19 Patients.
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DOI：
10.3390/v12121390
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发表时间：
2020-12-04
期刊：
影响因子：
--
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Hashem AM;Algaissi A;Almahboub SA;Alfaleh MA;Abujamel TS;Alamri SS;Alluhaybi KA;Hobani HI;AlHarbi RH;Alsulaiman RM;ElAssouli MZ;Hala S;Alharbi NK;Alhabbab RY;AlSaieedi AA;Abdulaal WH;Bukhari A;Al-Somali AA;Alofi FS;Khogeer AA;Pain A;Alkayyal AA;Almontashiri NAM;Ahmad BM;Li X
由SARS-CoV-2引起的冠状病毒病2019年(新冠肺炎)继续在全球传播，发病率和死亡率都很高。抗原特异性反应对新冠肺炎患者的临床治疗具有不容置疑的价值。在这里，我们研究了新冠肺炎住院患者中抗S蛋白(S)和核蛋白(N)蛋白的免疫球蛋白和免疫球蛋白的动力学及其中和能力，这些患者具有不同的疾病表现(即轻、中、重度)、需要入院重症监护病房(ICU)或转归(即生存与死亡)。我们发现，几乎所有具有不同临床表现的新冠肺炎患者都能很容易地检测到SARS-CoV-2特异性免疫球蛋白G、免疫球蛋白M和中和抗体(NAB)。有趣的是，在症状更严重的患者、需要住ICU的患者或那些有致命后果的患者中，NABS水平以及抗S1和-N免疫球蛋白和免疫球蛋白抗体水平显著升高。更重要的是，在症状出现后的早期，我们发现抗N抗体水平与疾病严重程度密切相关。总的来说，这些发现为了解不同疾病严重程度的新冠肺炎患者的抗体反应动力学提供了新的见解。
The Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2, continues to spread globally with significantly high morbidity and mortality rates. Antigen-specific responses are of unquestionable value for clinical management of COVID-19 patients. Here, we investigated the kinetics of IgM, IgG against the spike (S) and nucleoproteins (N) proteins and their neutralizing capabilities in hospitalized COVID-19 patients with different disease presentations (i.e., mild, moderate or severe), need for intensive care units (ICU) admission or outcomes (i.e., survival vs death). We show that SARS-CoV-2 specific IgG, IgM and neutralizing antibodies (nAbs) were readily detectable in almost all COVID-19 patients with various clinical presentations. Interestingly, significantly higher levels of nAbs as well as anti-S1 and -N IgG and IgM antibodies were found in patients with more severe symptoms, patients requiring admission to ICU or those with fatal outcomes. More importantly, early after symptoms onset, we found that the levels of anti-N antibodies correlated strongly with disease severity. Collectively, these findings provide new insights into the kinetics of antibody responses in COVID-19 patients with different disease severity.
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影响因子：
82.9
作者：
Long, Quan-Xin;Liu, Bai-Zhong;Huang, Ai-Long
通讯作者：
Huang, Ai-Long
影响因子：
13.2
作者：
Sun, Baoqing;Feng, Ying;Chen, Ling
通讯作者：
Chen, Ling
影响因子：
56.9
作者：
Yan, Renhong;Zhang, Yuanyuan;Zhou, Qiang
通讯作者：
Zhou, Qiang
DOI：
10.1038/nrmicro2090
发表时间：
2009-03
期刊：
Nature reviews. Microbiology
影响因子：
--
作者：
通讯作者：
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影响因子：
5.9
作者：
Cobey S;Hensley SE
通讯作者：
Hensley SE