Brain injury in autonomic, emotional, and cognitive regulatory areas in patients with heart failure.
Brain injury in autonomic, emotional, and cognitive regulatory areas in patients with heart failure.
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DOI：
10.1016/j.cardfail.2008.10.020
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发表时间：
2009-04
影响因子：
6
通讯作者：
Harper, Ronald M.
中科院分区：
文献类型：
--
作者：
Woo, Mary A.;Kumar, Rajesh;Macey, Paul M.;Fonarow, Gregg C.;Harper, Ronald M.
心力衰竭（HF）伴有自主神经、情感和认知缺陷，表明大脑改变。HF患者出现灰质体积减少和孤立性白色物质梗死，但损害程度尚不清楚。使用磁共振T2弛豫测量法，我们评估了HF患者整个脑的损伤程度。质子密度和T2加权图像采集自13例HF（年龄54.6 ± 8.3岁; 69%男性，LVEF 0.28 ± 0.07）和49例对照（50.6 ± 7.3岁，59%男性）。使用协方差分析（协变量：年龄和性别）比较各组之间每个体素的T2弛豫时间全脑图。较高的T2弛豫值表明受损的脑区（p < 0.005）出现在控制自主神经、镇痛、情绪和认知功能的部位（下丘脑、中缝大肌、小脑皮质、深核和蚓部;颞叶、顶叶、前额叶、枕叶、岛叶、扣带和腹侧额叶皮质;胼胝体;前丘脑;尾状核;前穹窿和海马）。对照组与HF受试者相比，没有脑区显示出更高的T2值。HF患者的自主神经、疼痛、情绪、语言和认知功能相关区域出现脑结构损伤。伴随HF的共病可能是由与综合征相关的神经损伤引起的。
Heart failure (HF) is accompanied by autonomic, emotional, and cognitive deficits, indicating brain alterations. Reduced gray matter volume and isolated white matter infarcts occur in HF, but the extent of damage is unclear. Using magnetic resonance T2 relaxometry, we evaluated the extent of injury across the entire brain in HF. Proton-density and T2-weighted images were acquired from 13 HF (age 54.6 ± 8.3 years; 69% male, LVEF 0.28 ± 0.07) and 49 controls (50.6 ± 7.3 years, 59% male). Whole brain maps of T2 relaxation times were compared at each voxel between groups using analysis of covariance (covariates: age and gender). Higher T2 relaxation values, indicating injured brain areas (p < 0.005), emerged in sites that control autonomic, analgesic, emotional, and cognitive functions (hypothalamus, raphé magnus, cerebellar cortex, deep nuclei and vermis; temporal, parietal, prefrontal, occipital, insular, cingulate, and ventral frontal cortices; corpus callosum; anterior thalamus; caudate nuclei; anterior fornix and hippocampus). No brain areas showed higher T2 values in control vs. HF subjects. Brain structural injury emerged in areas involved in autonomic, pain, mood, language, and cognitive function in HF patients. Comorbid conditions accompanying HF may result from neural injury associated with the syndrome.
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影响因子：
9.6
作者：
Ferrier, K;Campbell, A;Neill, A
通讯作者：
Neill, A
影响因子：
2.4
作者：
Gold, Stefan M.;Irwin, Michael R.
通讯作者：
Irwin, Michael R.
影响因子：
14.5
作者：
Critchley, HD;Mathias, CJ;Dolan, RJ
通讯作者：
Dolan, RJ
影响因子：
2.5
作者：
Critchley, HD
通讯作者：
Critchley, HD
DOI：
10.1076/jcen.25.1.14.13635
发表时间：
2003-02-01
影响因子：
2.2
作者：
Incalzi, RA;Trojano, L;Rengo, F
通讯作者：
Rengo, F