Select interneuron clusters determine female sexual receptivity in Drosophila.
Select interneuron clusters determine female sexual receptivity in Drosophila.
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DOI：
10.1038/ncomms2837
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发表时间：
2013
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
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带有老处女突变的雌性果蝇会排斥求爱的雄性果蝇，并且很少交配。在这里，我们表明，在野生型（老处女杂合）女性大脑中，通过消除自旋 A 或自旋 D 神经元簇的老处女功能，可以重现非交配表型。 Spin-D 对应于触角叶 VA1v 肾小球中具有树突的嗅觉投射神经元，其无果阳性、两性二态性并对苍蝇气味敏感。 Spin-A 是食管下神经节中的一种新型局部神经元簇，已知它可以处理接触化学信息素信息和交配相关信号。如果同时表达雷帕霉素的显性负性机制靶标，则将老处女表达稍微降低至影响最小的水平就足以关闭女性的性接受能力，尽管后者的单独操作仅具有边际效应。我们提出，这些神经元中雷帕霉素信号转导的自旋介导的机械靶点对于雌性接受雄性求爱至关重要。 蛋白质老处女与果蝇求偶行为有关。樱井和同事鉴定了两簇表达老处女的中间神经元，并表明这些细胞是女性接受男性进步所必需的。
Female Drosophila with the spinster mutation repel courting males and rarely mate. Here we show that the non-copulating phenotype can be recapitulated by the elimination of spinster functions from either spin-A or spin-D neuronal clusters, in the otherwise wild-type (spinster heterozygous) female brain. Spin-D corresponds to the olfactory projection neurons with dendrites in the antennal lobe VA1v glomerulus that is fruitless-positive, sexually dimorphic and responsive to fly odour. Spin-A is a novel local neuron cluster in the suboesophageal ganglion, which is known to process contact chemical pheromone information and copulation-related signals. A slight reduction in spinster expression to a level with a minimal effect is sufficient to shut off female sexual receptivity if the dominant-negative mechanistic target of rapamycin is simultaneously expressed, although the latter manipulation alone has only a marginal effect. We propose that spin-mediated mechanistic target of rapamycin signal transduction in these neurons is essential for females to accept the courting male. The protein spinster is implicated in Drosophila courtship behaviour. Sakurai and colleagues identify two clusters of spinster-expressing interneurons, and show that these cells are required for female receptivity to male advances.
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影响因子：
9.2
作者：
Rezaval, Carolina;Pavlou, Hania J.;Dornan, Anthony J.;Chan, Yick-Bun;Kravitz, Edward A.;Goodwin, Stephen F.
通讯作者：
Goodwin, Stephen F.
影响因子：
9.2
作者：
Carvalho, GB;Kapahi, P;Benzer, S
通讯作者：
Benzer, S
影响因子：
16.2
作者：
Kimura, Ken-ichi;Hachiya, Tomoaki;Yamamoto, Daisuke
通讯作者：
Yamamoto, Daisuke
影响因子：
56.9
作者：
van Doorn, G. Sander;Edelaar, Pim;Weissing, Franz J.
通讯作者：
Weissing, Franz J.
影响因子：
64.8
作者：
Kurtovic, Amina;Widmer, Alexandre;Dickson, Barry J.
通讯作者：
Dickson, Barry J.