Neural circuitry underlying Drosophila female postmating behavioral responses.
Neural circuitry underlying Drosophila female postmating behavioral responses.
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DOI：
10.1016/j.cub.2012.04.062
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发表时间：
2012-07-10
期刊：
影响因子：
9.2
通讯作者：
Goodwin, Stephen F.
中科院分区：
文献类型：
--
作者：
Rezaval, Carolina;Pavlou, Hania J.;Dornan, Anthony J.;Chan, Yick-Bun;Kravitz, Edward A.;Goodwin, Stephen F.
交配后，雌性果蝇经历了显著的表型转换，导致性接受能力下降，产卵增加。交配过程中雄性性肽(SP)的转移通过共同表达雌性生殖系统中性别决定基因无果(FRU)和本体感受性神经元标记PPK(PPK)的感觉神经元来介导这些交配后反应。关于将SP感官信息传递到中枢电路的神经通路，以及这些信息是如何被处理以指导雌性特有的交配反应的变化，人们知之甚少。我们证明了表达性别决定基因Doublesex(Dsx)的神经元在调节雌性交配后反应中所起的重要作用。我们发现，在生殖系统中，dsx和前面描述的SP反应的fru+/PPK+表达神经元的一个子集之间存在共享的电路。此外，我们还鉴定了腹神经节(ABG)内的性二型dsx环路，这对调节交配后的反应至关重要。其中一些神经元定位于大脑的后部，而另一些则投射到子宫。我们认为，从感知SP到将该信号传递到更高阶的电路进行处理，直到产生后交配行为和生理输出，都需要由DSX指定的电路来诱导雌性交配行为反应。►通路在雌性后交配开关►外周交配交配神经元中起着关键作用，►中枢交配交配神经元对性肽的检测和反应将这一信号传递到高级处理和直接交配反应中。
After mating, Drosophila females undergo a remarkable phenotypic switch resulting in decreased sexual receptivity and increased egg laying. Transfer of male sex peptide (SP) during copulation mediates these postmating responses via sensory neurons that coexpress the sex-determination gene fruitless (fru) and the proprioceptive neuronal marker pickpocket (ppk) in the female reproductive system. Little is known about the neuronal pathways involved in relaying SP-sensory information to central circuits and how these inputs are processed to direct female-specific changes that occur in response to mating. We demonstrate an essential role played by neurons expressing the sex-determination gene doublesex (dsx) in regulating the female postmating response. We uncovered shared circuitry between dsx and a subset of the previously described SP-responsive fru+/ppk+-expressing neurons in the reproductive system. In addition, we identified sexually dimorphic dsx circuitry within the abdominal ganglion (Abg) critical for mediating postmating responses. Some of these dsx neurons target posterior regions of the brain while others project onto the uterus. We propose that dsx-specified circuitry is required to induce female postmating behavioral responses, from sensing SP to conveying this signal to higher-order circuits for processing and through to the generation of postmating behavioral and physiological outputs. ► dsx circuitry plays a pivotal role in the female postmating switch ► Peripheral dsx neurons detect and respond to sex peptide ► Central dsx neurons convey this signal to higher-order processing and direct postmating responses.
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DOI：
10.1073/pnas.1631700100
发表时间：
2003-08-19
影响因子：
11.1
作者：
Liu, HF;Kubli, E
通讯作者：
Kubli, E
影响因子：
2.2
作者：
BOULETREAUMERLE, J
通讯作者：
BOULETREAUMERLE, J
影响因子：
9.2
作者：
Rideout, Elizabeth J.;Billeter, Jean-Christophe;Goodwin, Stephen F.
通讯作者：
Goodwin, Stephen F.
影响因子：
2.7
作者：
Monastirioti, M
通讯作者：
Monastirioti, M
DOI：
10.1073/pnas.76.7.3430
发表时间：
1979-01-01
影响因子：
11.1
作者：
SIEGEL, RW;HALL, JC
通讯作者：
HALL, JC