Endoscopic and clinicopathological characteristics of colorectal T/NK cell lymphoma.
Endoscopic and clinicopathological characteristics of colorectal T/NK cell lymphoma.
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DOI：
10.1186/s13000-020-01044-5
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发表时间：
2020-10-21
影响因子：
2.6
通讯作者：
Takeshita M
中科院分区：
文献类型：
--
作者：
Ishibashi H;Nimura S;Hirai F;Harada N;Iwasaki H;Kawauchi S;Oshiro Y;Matsuyama A;Nakamura S;Takamatsu Y;Yonemasu H;Shimokama T;Takeshita M
结直肠T/自然杀伤（NK）细胞淋巴瘤（TNKCL）非常罕见。结直肠TNKCL的内镜和临床病理特征尚未明确证实。在这项研究中，我们展示了结直肠TNKCL的临床特征。对27例结直肠单形性肠嗜上皮性T细胞淋巴瘤（MEITL）、成人T细胞白血病/淋巴瘤（ATLL）和其他类型TNKCL患者的内镜和临床病理特征进行了研究。9名TNKCL患者（33%）被归类为MEITL，11名（41%）为ATLL，7名（26%）为其他。另一组包括4例EB病毒阳性（EBV+）TNKCL患者，2例惰性T细胞淋巴增殖性疾病和1例间变性大细胞淋巴瘤。内镜下6例MEITL（67%）和5例ATLL（46%）表现为弥漫浸润型，其中MEITL以黏膜水肿为主，ATLL以黏膜水肿和口疮样糜烂为主。在其他4例患者（57%）中确定了溃疡型，包括2例EBV+ TNKCL。在7名MEITL（88%）和6名ATLL（60%）患者中观察到非典型T上皮内淋巴细胞（T-IELS）增加，但在另一组（0%）患者中未观察到。5名MEITL患者（56%）表现出淋巴细胞性直肠结肠炎的特征，CD 8 + T-IEL增加。MEITL和ATLL偶尔侵犯结直肠，并观察到原发性累及MEITL。MEITL和ATLL的内镜表现以弥漫浸润型为主，而ATLL的内镜表现以溃疡型为主。淋巴细胞性直肠结肠炎的特征可能是MEITL的前驱表现。
Colorectal T/natural killer (NK)-cell lymphomas (TNKCL) are very rare. Endoscopic and clinicopathological characteristics of colorectal TNKCL have not been clearly demonstrated. In this study, we demonstrated the clinical characteristics of colorectal TNKCL. Endoscopic and clinicopathological characteristics were investigated in 27 patients with colorectal monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), adult T-cell leukemia/lymphoma (ATLL), and other types of TNKCL. Nine TNKCL patients (33%) were classified as MEITL, 11 (41%) as ATLL, and seven (26%) as other. Four patients with Epstein-Barr Virus-positive (EBV+) TNKCL, two indolent T-cell lymphoproliferative disorder and one anaplastic large cell lymphoma were included in the other group. Endoscopically, six MEITL (67%) and five ATLL (46%) showed diffuse-infiltrating type, in which the main endoscopic lesion was edematous mucosa in MEITL, while aphthoid erosion and edematous mucosa were typical in ATLL. Ulcerative type was identified in four other group patients (57%), including two EBV+ TNKCL. An increase in atypical T-intraepithelial lymphocytes (T-IELs) was noted in seven MEITL (88%) and six ATLL (60%) patients, but not in the other group (0%) patients. Five MEITL patients (56%) showed features of lymphocytic proctocolitis with increased CD8+ T-IELs. MEITL and ATLL occasionally invaded the colorectum, and primary involving MEITL was observed. Diffuse infiltrating type was the characteristic endoscopic finding in colorectal MEITL and ATLL, while ulcerative type was observed in the other group. Features of lymphocytic proctocolitis may be prodromal findings of MEITL.
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影响因子：
3.4
作者：
Hong YS;Woo YS;Park G;Lee K;Kang SH;Lee HW;Kim ER;Hong SN;Chang DK;Kim YH;Rhee PL;Kim JJ
通讯作者：
Kim JJ
影响因子：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
Kwong, Yok-Lam