Antibiotic Treatment in Anopheles coluzzii Affects Carbon and Nitrogen Metabolism.
Antibiotic Treatment in Anopheles coluzzii Affects Carbon and Nitrogen Metabolism.
复制标题
DOI：
10.3390/pathogens9090679
复制
发表时间：
2020-08-21
期刊：
影响因子：
--
通讯作者：
Gendrin M
中科院分区：
文献类型：
--
作者：
Chabanol E;Behrends V;Prévot G;Christophides GK;Gendrin M
蚊子微生物群降低了按蚊传播疟原虫的媒介能力，并影响宿主健康；因此，它被视为减少疟疾传播的潜在目标。虽然免疫诱导、抗菌药物的分泌和代谢竞争是哺乳动物中微生物群介导的针对侵入性病原体的保护的三种典型机制，但蚊子-微生物群和微生物群-疟原虫相互作用中代谢竞争或互利关系的参与尚未得到研究。在这里，我们描述了在常规或抗生素治疗的条件下，对提供糖粉或非感染性血粉的库氏按蚊中肠进行的代谢组分析。我们观察到抗生素治疗会影响三羧酸循环和氮代谢，特别是导致游离氨基酸丰度降低。将我们的结果与已发表的数据联系起来，我们确定了可能通过代谢相互作用或免疫调节参与微生物群-疟原虫相互作用的途径，因此将成为未来功能研究的有趣候选者。
The mosquito microbiota reduces the vector competence of Anopheles to Plasmodium and affects host fitness; it is therefore considered as a potential target to reduce malaria transmission. While immune induction, secretion of antimicrobials and metabolic competition are three typical mechanisms of microbiota-mediated protection against invasive pathogens in mammals, the involvement of metabolic competition or mutualism in mosquito-microbiota and microbiota-Plasmodium interactions has not been investigated. Here, we describe a metabolome analysis of the midgut of Anopheles coluzzii provided with a sugar-meal or a non-infectious blood-meal, under conventional or antibiotic-treated conditions. We observed that the antibiotic treatment affects the tricarboxylic acid cycle and nitrogen metabolism, notably resulting in decreased abundance of free amino acids. Linking our results with published data, we identified pathways which may participate in microbiota-Plasmodium interactions via metabolic interactions or immune modulation and thus would be interesting candidates for future functional studies.
登录
查看更多内容
影响因子：
15.5
作者：
Bascuñán P;Niño-Garcia JP;Galeano-Castañeda Y;Serre D;Correa MM
通讯作者：
Correa MM
影响因子：
3.2
作者：
Gimonneau, Geoffrey;Tchioffo, Majoline T.;Morlais, Isabelle
通讯作者：
Morlais, Isabelle
影响因子：
3.7
作者：
Akorli J;Gendrin M;Pels NA;Yeboah-Manu D;Christophides GK;Wilson MD
通讯作者：
Wilson MD
影响因子：
2.1
作者：
BEIER, MS;PUMPUNI, CB;DAVIS, JR
通讯作者：
DAVIS, JR
影响因子：
7.4
作者：
Kind, Tobias;Wohlgemuth, Gert;Lee, Do Yup;Lu, Yun;Palazoglu, Mine;Shahbaz, Sevini;Fiehn, Oliver
通讯作者：
Fiehn, Oliver