Antibacterial and Anti-biofilm Activity of the Human Breast Milk Glycoprotein Lactoferrin against Group B Streptococcus.
Antibacterial and Anti-biofilm Activity of the Human Breast Milk Glycoprotein Lactoferrin against Group B Streptococcus.
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DOI：
10.1002/cbic.202100016
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发表时间：
2021-06-15
期刊：
影响因子：
--
通讯作者：
Gaddy JA
中科院分区：
文献类型：
--
作者：
Lu J;Francis JD;Guevara MA;Moore RE;Chambers SA;Doster RS;Eastman AJ;Rogers LM;Noble KN;Manning SD;Damo SM;Aronoff DM;Townsend SD;Gaddy JA
B族链球菌（GBS）是一种包封的革兰氏阳性人类病原体，其在妊娠宿主和新生儿以及免疫功能低下的个体中引起侵袭性感染。人类宿主的定殖需要粘附于粘膜表面并绕过与先天免疫应答相关的营养挑战和抗微生物冲击的能力。生物膜的形成是促进GBS在脊椎动物宿主中存活和建立复制生态位的关键过程。先前的研究表明，宿主通过产生先天性抗微生物糖蛋白乳铁蛋白来响应GBS感染，乳铁蛋白参与抑制细菌生长和生物膜形成。此外，乳铁蛋白在人类母乳中非常丰富，可以起到保护作用，抵御入侵的微生物病原体。我们的工作表明，人乳铁蛋白具有抗GBS的抗微生物和抗生物膜活性，并抑制GBS粘附到人妊娠膜。总之，这些结果表明人乳乳铁蛋白可用作益生元化疗策略，以限制细菌粘附和生物膜形成对GBS相关疾病结果的影响。
Group B Streptococcus (GBS) is an encapsulated gram-positive human pathogen which causes invasive infections in pregnant hosts and neonates, as well as immunocompromised individuals. Colonization of the human host requires the ability to adhere to mucosal surfaces and circumnavigate the nutritional challenges and antimicrobial onslaught associated with the innate immune response. Biofilm formation is a critical process to facilitate GBS survival and establishment of a replicative niche in the vertebrate host. Previous work has shown that the host responds to GBS infection by producing the innate antimicrobial glycoprotein lactoferrin, which has been implicated in repressing bacterial growth and biofilm formation. Additionally, lactoferrin is highly abundant in human breast milk and could serve a protective role against invasive microbial pathogens. Our work demonstrates that human breast milk lactoferrin has antimicrobial and anti-biofilm activity against GBS and inhibits GBS adherence to human gestational membranes. Together these results indicate that human milk lactoferrin could be utilized as a prebiotic chemotherapeutic strategy to limit the impact of bacterial adherence and biofilm formation on GBS-associated disease outcomes.
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影响因子：
5.3
作者：
Ackerman DL;Craft KM;Doster RS;Weitkamp JH;Aronoff DM;Gaddy JA;Townsend SD
通讯作者：
Townsend SD
影响因子：
3
作者：
Andreini, Claudia;Bertini, Ivano;Thornton, Janet M.
通讯作者：
Thornton, Janet M.
影响因子：
2
作者：
Albenzio, Marzia;Santillo, Antonella;Magaldi, Rosario
通讯作者：
Magaldi, Rosario
影响因子：
6.4
作者：
Doster, Ryan S.;Kirk, Leslie A.;Gaddy, Jennifer A.
通讯作者：
Gaddy, Jennifer A.
影响因子：
2.9
作者：
Hwang, Shen-An;Kruzel, Marian L.;Actor, Jeffrey K.
通讯作者：
Actor, Jeffrey K.