Arabidopsis thaliana and Pseudomonas Pathogens Exhibit Stable Associations over Evolutionary Timescales.
Arabidopsis thaliana and Pseudomonas Pathogens Exhibit Stable Associations over Evolutionary Timescales.
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DOI：
10.1016/j.chom.2018.06.011
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发表时间：
2018-07-11
影响因子：
30.3
通讯作者：
Weigel D
中科院分区：
文献类型：
--
作者：
Karasov TL;Almario J;Friedemann C;Ding W;Giolai M;Heavens D;Kersten S;Lundberg DS;Neumann M;Regalado J;Neher RA;Kemen E;Weigel D
作物病害的爆发往往与单一病原谱系的克隆扩张有关。为了确定是否类似的繁荣和萧条的情况下举行的野生病理系统，我们进行了多年，多地点的调查假单胞菌在其天然宿主拟南芥。最常见的假单胞菌谱系对应于一个普遍存在的致病分支。对1，524个基因组的测序显示，这一谱系在大约30万年前已经多样化，包含数十个遗传上可识别的致病亚系。在基因含量和疾病表型水平上存在分化，尽管这种分化可能不会为特定的亚系提供适合性优势。亚系的共存表明，与作物系统相反，在最近的过去，没有一个菌株能够超过所研究的拟南芥种群。我们的研究结果表明，选择压力作用于植物病原体在野生宿主可能比那些在农业系统中复杂得多。野生拟南芥经常被单一的假单胞菌属OTU菌株定殖，该OTU中的菌株至少在30万年前彼此分化。许多菌株可以引起疾病并被归类为病原性的。与农业相反，没有单一的病原性菌株主导宿主种群。在这项研究中，Karasov et al.表明在野生植物的种群中，没有一个单一的丰富的病原体谱系接管宿主种群。遗传和物种多样性可能会阻止自然界中的克隆扩张。
Crop disease outbreaks are often associated with clonal expansions of single pathogenic lineages. To determine whether similar boom-and-bust scenarios hold for wild pathosystems, we carried out a multi-year, multi-site survey of Pseudomonas in its natural host Arabidopsis thaliana. The most common Pseudomonas lineage corresponded to a ubiquitous pathogenic clade. Sequencing of 1,524 genomes revealed this lineage to have diversified approximately 300,000 years ago, containing dozens of genetically identifiable pathogenic sublineages. There is differentiation at the level of both gene content and disease phenotype, although the differentiation may not provide fitness advantages to specific sublineages. The coexistence of sublineages indicates that in contrast to crop systems, no single strain has been able to overtake the studied A. thaliana populations in the recent past. Our results suggest that selective pressures acting on a plant pathogen in wild hosts are likely to be much more complex than those in agricultural systems. Wild A. thaliana is regularly colonized by a single Pseudomonas OTU Strains within this OTU diverged from one another at least 300,000 years ago Many strains can cause disease and are classified as pathogenic In contrast to agriculture, no single pathogenic strain dominates host populations Disease outbreaks in agriculture are often associated with clonal expansions of single pathogenic lineages. In this study, Karasov et al. show that in populations of a wild plant, no single lineage of an abundant pathogen takes over the host population. Genetic and species diversity may prevent clonal expansions in nature.
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DOI：
10.1073/pnas.1710455114
发表时间：
2017-10-31
影响因子：
11.1
作者：
Almario J;Jeena G;Wunder J;Langen G;Zuccaro A;Coupland G;Bucher M
通讯作者：
Bucher M
影响因子：
6.7
作者：
Baltrus DA;Nishimura MT;Romanchuk A;Chang JH;Mukhtar MS;Cherkis K;Roach J;Grant SR;Jones CD;Dangl JL
通讯作者：
Dangl JL
影响因子：
2.4
作者：
ANDERSON, RM;MAY, RM
通讯作者：
MAY, RM
DOI：
10.1073/pnas.1731982100
发表时间：
2003-09-02
影响因子：
11.1
作者：
Buell, CR;Joardar, V;Collmer, A
通讯作者：
Collmer, A
影响因子：
5.1
作者：
Bartoli, Claudia;Berge, Odile;Morris, Cindy E.
通讯作者：
Morris, Cindy E.