Immunologic aspects of otitis media with effusion: characteristics of lymphocyte and macrophage reactivity.
Immunologic aspects of otitis media with effusion: characteristics of lymphocyte and macrophage reactivity.
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渗出性中耳炎的免疫学方面：淋巴细胞和巨噬细胞反应性的特征。
DOI：
10.1093/infdis/145.6.804
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Ogra,PL
中科院分区：
文献类型：
--
作者：
Yamanaka,T;Bernstein,JB;Cumella,J;Parker,C;Ogra,PL
本文检测了50例慢性中耳炎患者中耳积液、外周血和腺样体组织中细胞成分的特征及中耳巨噬细胞对淋巴细胞功能活性的影响。巨噬细胞是中耳积液的主要细胞类型，占细胞总数的63%。T细胞占细胞总数的11% ~ 66%。与外周血和腺样体淋巴细胞相比，植物血凝素或美洲商陆丝裂原诱导的中耳淋巴细胞的增殖反应普遍较低。中耳巨噬细胞与腺样淋巴细胞共培养可显著抑制淋巴细胞的增殖反应和免疫球蛋白合成。这些观察结果表明，中耳巨噬细胞可能对中耳积液性中耳炎患者免疫反应的调节有深远的影响。
The characteristics of cellular elements in the middle ear effusions, peripheral blood, and adenoidal tissue and the effects of middle ear macrophages on the functional activity of lymphocytes were examined in 50 subjects with chronic otitis media. Macrophages were the predominant cell type in middle ear effusions, and they constituted up to 63% of the total number of cells. T cells were 11%–66% of the total number of cells. The proliferative responses induced by phytohemagglutinin or pokeweed mitogen in middle ear lymphocytes were generally low compared with the responses observed in peripheral blood and adenoidal lymphocytes. Cocultures of middle ear macrophages with adenoidal lymphocytes resulted in a significant depression of proliferative response and immunoglobulin synthesis in the lymphocytes. These observations suggest that macrophages in the middle ear may have a profound influence on the regulation of the immune response in the middle ear in patients who have otitis media with effusion.
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美洲商陆有丝分裂原诱导的免疫球蛋白分泌细胞与人外周血单核细胞的分化的单核细胞依赖性。
影响因子：
4.4
作者：
S. Rosenberg;P. Lipsky
通讯作者：
P. Lipsky
单核细胞在有丝分裂原激活人淋巴细胞中的作用。
影响因子：
4.4
作者：
J. D. de Vries;A. Caviles;W. S. Bont;J. Mendelsohn
通讯作者：
J. Mendelsohn
美洲商陆有丝分裂原诱导人 B 细胞分化：通过蛋白 A 溶血斑测定进行评估。
影响因子：
6.4
作者：
L. Hammarström;A. Bird;S. Britton;C. I. Smith
通讯作者：
C. I. Smith
儿童急性中耳炎的免疫反应Ⅲ．
影响因子：
4.4
作者：
J. Sloyer;V. Howie;J. H. Ploussard;J. Bradac;M. Habercorn;P. Ogra
通讯作者：
P. Ogra
急性中耳炎的免疫学和微生物学
DOI：
10.1177/00034894760850s224
发表时间：
1976
期刊：
Annals of Otology, Rhinology & Laryngology
影响因子：
--
作者：
J. Sloyer;J. H. Ploussard;V. Howie
通讯作者：
V. Howie