Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study.
Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study.
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DOI：
10.3390/nu13020384
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发表时间：
2021-01-26
期刊：
影响因子：
5.9
通讯作者：
Harris WS
中科院分区：
文献类型：
--
作者：
Farrell SW;DeFina LF;Tintle NL;Leonard D;Cooper KH;Barlow CE;Haskell WL;Pavlovic A;Harris WS
背景：长链omega-3多不饱和脂肪酸（n-3 PUFA）与前列腺癌（PC）之间的关系尚不清楚。方法：我们比较了在库珀诊所就诊的5607名（40-80岁）基线时没有PC的男性的PC发生率与Omega-3指数[O3I，红细胞二十碳五烯酸和二十二碳六烯酸（EPA + DHA）]的关系。平均随访时间为5.1±2.8年，直至复查或报告新的PC诊断。采用比例风险回归对基线O3I与年龄调整后诊断时间之间的线性关系进行建模。基于n-3 PUFA生物标志物的研究和事件PC的荟萃分析更新了本研究结果。结果：共发现116例外伤性PC。当O3I作为一个连续变量进行检查时，每增加1%的O3I，年龄调整风险比（HR） （95% CI）为0.98 （0.89,1.07;p = 0.25）。10项基于生物标志物的研究的最新荟萃分析发现，EPA或DHA水平与PC风险之间没有显著关系。结论：我们在本研究和类似研究的荟萃分析中均未发现食用富含n-3 pufa的鱼类或使用鱼油补充剂会影响PC风险的证据。
Background: The association between long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) and prostate cancer (PC) remains unclear. Methods: We compared incident PC rates as a function of the Omega-3 Index [O3I, erythrocyte eicosapentaenoic and docosahexaenoic acids (EPA + DHA)] in 5607 men (40–80 years of age) seen at the Cooper Clinic who were free of PC at baseline. The average follow-up was 5.1 ± 2.8 years until censoring or reporting a new PC diagnosis. Proportional hazards regression was used to model the linear association between baseline O3I and the age-adjusted time to diagnosis. A meta-analysis of n-3 PUFA biomarker-based studies and incident PC was updated with the present findings. Results: A total of 116 cases of incident PC were identified. When O3I was examined as a continuous variable, the age-adjusted hazard ratio (HR) (95% CI) was 0.98 (0.89, 1.07; p = 0.25) for each 1% increment in the O3I. The updated meta-analysis with 10 biomarker-based studies found no significant relationship between EPA or DHA levels and risk for PC. Conclusions: We find no evidence in this study nor in a meta-analysis of similar studies that consuming n-3 PUFA-rich fish or using fish oil supplements affects the risk of PC.
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5.2
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通讯作者：
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作者：
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