Human Cognitive Ability Is Modulated by Aromatase Availability in the Brain in a Sex-Specific Manner.
Human Cognitive Ability Is Modulated by Aromatase Availability in the Brain in a Sex-Specific Manner.
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DOI：
10.3389/fnins.2020.565668
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发表时间：
2020
影响因子：
4.3
通讯作者：
Biegon A
中科院分区：
文献类型：
--
作者：
Alia-Klein N;Preston-Campbell RN;Kim SW;Pareto D;Logan J;Wang GJ;Moeller SJ;Fowler JS;Biegon A
芳香酶催化雌激素生物合成的最后一步，将睾酮转化为雌二醇，并在所有哺乳动物的大脑中表达。雌激素被认为对维持女性的认知功能很重要，而睾酮被认为调节男性的认知能力。在这里，我们比较了健康男性和女性的认知能力与大脑芳香化酶可用性的差异。对27名健康参与者进行了言语学习和记忆以及知觉/抽象推理测试。使用正电子发射断层扫描（PET）和经验证的芳香酶放射性示踪剂[11 C]伏罗唑，在该样本中获得脑芳香酶可用性的体内图像。感兴趣的区域被放置在杏仁核和丘脑的两侧，其中芳香化酶在人脑中的可用性最高。虽然认知能力和芳香化酶的可用性没有性别差异，但杏仁核中芳香化酶的可用性较高与男性认知能力较低相关。在女性中没有发现这种关系;相应的回归斜率在性别之间存在显着差异。丘脑芳香化酶的可用性与两种性别的认知能力均无显著相关性。这些研究结果表明，脑芳香化酶对认知能力的影响是区域和性别特异性的，可以解释男性和女性语言和非语言认知能力的一些正常差异，以及与阿尔茨海默病相关的认知下降轨迹的性别差异。
The enzyme aromatase catalyzes the final step in estrogen biosynthesis, converting testosterone to estradiol, and is expressed in the brain of all mammals. Estrogens are thought to be important for maintenance of cognitive function in women, whereas testosterone is thought to modulate cognitive abilities in men. Here, we compare differences in cognitive performance in relation to brain aromatase availability in healthy men and women. Twenty-seven healthy participants were administered tests of verbal learning and memory and perceptual/abstract reasoning. In vivo images of brain aromatase availability were acquired in this sample using positron emission tomography (PET) with the validated aromatase radiotracer [11C]vorozole. Regions of interest were placed bilaterally on the amygdala and thalamus where aromatase availability is highest in the human brain. Though cognitive performance and aromatase availability did not differ as a function of sex, higher availability of aromatase in the amygdala was associated with lower cognitive performance in men. No such relationship was found in women; and the corresponding regression slopes were significantly different between the sexes. Thalamic aromatase availability was not significantly correlated with cognitive performance in either sex. These findings suggest that the effects of brain aromatase on cognitive performance are both region- and sex-specific and may explain some of the normal variance seen in verbal and nonverbal cognitive abilities in men and women as well as sex differences in the trajectory of cognitive decline associated with Alzheimer’s disease.
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从杏仁核中的电路到行为。
影响因子：
64.8
作者：
Janak PH;Tye KM
通讯作者：
Tye KM
影响因子：
2.9
作者：
Alejandre-Gomez, Misael;Garcia-Segura, Luis Miguel;Gonzalez-Burgos, Ignacio
通讯作者：
Gonzalez-Burgos, Ignacio
影响因子：
10.6
作者：
Biegon, Anat;Kim, Sung-Won;Logan, Jean;Hooker, Jacob M.;Muench, Lisa;Fowler, Joanna S.
通讯作者：
Fowler, Joanna S.
影响因子：
3.7
作者：
McCarrey, Anna C.;An, Yang;Resnick, Susan M.
通讯作者：
Resnick, Susan M.
DOI：
10.1016/s0960-0760(03)00359-5
发表时间：
2003-09-01
影响因子：
4.1
作者：
Bulun, SE;Sebastian, S;Shozu, M
通讯作者：
Shozu, M