Variations of chromosomes 2 and 3 gene expression profiles among pulmonary telocytes, pneumocytes, airway cells, mesenchymal stem cells and lymphocytes.
Variations of chromosomes 2 and 3 gene expression profiles among pulmonary telocytes, pneumocytes, airway cells, mesenchymal stem cells and lymphocytes.
复制标题
肺特细胞、肺细胞、气道细胞、间充质干细胞和淋巴细胞中2号和3号染色体基因表达谱的变异
DOI：
10.1111/jcmm.12429
复制
发表时间：
2014-10
影响因子：
5.3
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Zheng M;Sun X;Zhang M;Qian M;Zheng Y;Li M;Cretoiu SM;Chen C;Chen L;Cretoiu D;Popescu LM;Fang H;Wang X
端细胞（Telocytes，TC）是间质组织中一种独特的细胞类型，具有极长的端足（telopodes，Tps）。我们以前的数据表明，模式的小鼠TC特异性基因的1号染色体上的档案。本研究的重点是确定的特征和模式的TC特异性或TC主导的基因表达谱在染色体2和3，网络的主要基因和潜在的功能协会。我们比较了肺TC、间充质干细胞、成纤维细胞、肺泡II型细胞、气道基底细胞、近端气道细胞、来自支气管淋巴结的CD 8 +T细胞（T-BL）和来自肺的CD 8 + T细胞（T-LL）的基因表达谱。与其他细胞相比，第2号染色体上有26或80个TC基因表达上调，第3号染色体上有13或59个TC基因表达下调。与其他细胞不同的是，Myl 9在TCs的2号染色体上明显过表达，表明TCs的生物学功能主要与组织/器官损伤和衰老有关，而Pltp的表达下调意味着TCs可能与抑制或减轻肺部炎症有关。TCs 3号染色体上Sh 3glb 1、Tm 4sf 1或Csf 1的显性过表达主要与肺癌的肿瘤促进相关，而Pde 5的大部分表达下调可能参与肺纤维化和其他急、慢性间质性肺疾病的发展。
Telocytes (TCs) were identified as a distinct cellular type of the interstitial tissue and defined as cells with extremely long telopodes (Tps). Our previous data demonstrated patterns of mouse TC-specific gene profiles on chromosome 1. The present study focuses on the identification of characters and patterns of TC-specific or TC-dominated gene expression profiles in chromosome 2 and 3, the network of principle genes and potential functional association. We compared gene expression profiles of pulmonary TCs, mesenchymal stem cells, fibroblasts, alveolar type II cells, airway basal cells, proximal airway cells, CD8+T cells from bronchial lymph nodes (T-BL), and CD8+ T cells from lungs (T-LL). We identified that 26 or 80 genes of TCs in chromosome 2 and 13 or 59 genes of TCs up-or down-regulated in chromosome 3, as compared with other cells respectively. Obvious overexpression of Myl9 in chromosome 2 of TCs different from other cells, indicates that biological functions of TCs are mainly associated with tissue/organ injury and ageing, while down-expression of Pltp implies that TCs may be associated with inhibition or reduction of inflammation in the lung. Dominant overexpression of Sh3glb1, Tm4sf1 or Csf1 in chromosome 3 of TCs is mainly associated with tumour promotion in lung cancer, while most down-expression of Pde5 may be involved in the development of pulmonary fibrosis and other acute and chronic interstitial lung disease.
登录
查看更多内容
影响因子：
5.3
作者：
Chen X;Zheng Y;Manole CG;Wang X;Wang Q
通讯作者：
Wang Q
影响因子：
3.6
作者：
Hinescu, Mihail E.;Gherghiceanu, Mihaela;Suciu, Laura;Popescu, Laurentiu M.
通讯作者：
Popescu, Laurentiu M.
影响因子：
5.3
作者：
Díaz-Flores L;Gutiérrez R;Sáez FJ;Díaz-Flores L Jr;Madrid JF
通讯作者：
Madrid JF
影响因子：
21.3
作者：
Hergenreider, Eduard;Heydt, Susanne;Dimmeler, Stefanie
通讯作者：
Dimmeler, Stefanie
影响因子：
5.3
作者：
Luesma MJ;Gherghiceanu M;Popescu LM
通讯作者：
Popescu LM