Telocytes in neuromuscular spindles.
Telocytes in neuromuscular spindles.
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DOI：
10.1111/jcmm.12015
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发表时间：
2013-04
影响因子：
5.3
通讯作者：
Madrid JF
中科院分区：
文献类型：
--
作者：
Díaz-Flores L;Gutiérrez R;Sáez FJ;Díaz-Flores L Jr;Madrid JF
最近在各种基质组织中发现了一种新的细胞类型，称为端细胞（TC）。本研究的目的是调查通过光（常规和免疫组化程序）和电子显微镜的成年人神经肌肉梭（NMS）的TC的存在，并奠定了基础，为未来的研究在人类胎儿发育和骨骼肌病理学的行为。在NMS中观察到大量TC，其超微结构特征为非常长的、最初较薄的念珠状突起（端足- Tps），其中薄节（足节）与扩张（足节）交替。TC形成外部NMS囊和整个NMS内囊的最内层和（部分）最外层。在后者中，Tps被组织在一个密集的网络中，该网络包围梭内横纹肌细胞、神经纤维和血管，这表明它们在控制NMS活动中具有被动和主动的作用，包括它们参与细胞间信号传导。免疫组化，TC表达波形蛋白，CD 34和偶尔c-kit/CD 117。在人类胎儿（胎龄22-23周）中，TC和神经周细胞形成鞘，作为梭内结构的互连引导。在病理条件下，CD 34阳性TC的数量增加，残留NMS之间的浸润性肌肉腱膜纤维瘤病和不同的NMS周围的淋巴细胞浸润炎性肌病。我们的结论是，在横纹肌细胞，神经和血管汇聚的NMS中，TC数量众多，这为TC研究提供了理想的显微解剖结构。
A new cell type named telocyte (TC) has recently been identified in various stromal tissues, including skeletal muscle interstitium. The aim of this study was to investigate by means of light (conventional and immunohistochemical procedures) and electron microscopy the presence of TCs in adult human neuromuscular spindles (NMSs) and lay the foundations for future research on their behaviour during human foetal development and in skeletal muscle pathology. A large number of TCs were observed in NMSs and were characterized ultrastructurally by very long, initially thin, moniliform prolongations (telopodes – Tps), in which thin segments (podomeres) alternated with dilations (podoms). TCs formed the innermost and (partially) the outermost layers of the external NMS capsule and the entire NMS internal capsule. In the latter, the Tps were organized in a dense network, which surrounded intrafusal striated muscle cells, nerve fibres and vessels, suggesting a passive and active role in controlling NMS activity, including their participation in cell-to-cell signalling. Immunohistochemically, TCs expressed vimentin, CD34 and occasionally c-kit/CD117. In human foetus (22–23 weeks of gestational age), TCs and perineural cells formed a sheath, serving as an interconnection guide for the intrafusal structures. In pathological conditions, the number of CD34-positive TCs increased in residual NMSs between infiltrative musculoaponeurotic fibromatosis and varied in NMSs surrounded by lymphocytic infiltrate in inflammatory myopathy. We conclude that TCs are numerous in NMSs (where striated muscle cells, nerves and vessels converge), which provide an ideal microanatomic structure for TC study.
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影响因子：
3.6
作者：
Hinescu, Mihail E.;Gherghiceanu, Mihaela;Suciu, Laura;Popescu, Laurentiu M.
通讯作者：
Popescu, Laurentiu M.
特细胞是 PEComas 和 GIST 的共同起源细胞：这是一个有证据支持的假设。
影响因子：
5.3
作者：
Ardeleanu C;Bussolati G
通讯作者：
Bussolati G
影响因子：
5.3
作者：
Kostin S
通讯作者：
Kostin S
DOI：
10.1111/j.1582-4934.2006.tb00306.x
发表时间：
2006-01
影响因子：
5.3
作者：
Hinescu ME;Gherghiceanu M;Mandache E;Ciontea SM;Popescu LM
通讯作者：
Popescu LM
影响因子：
2.5
作者：
KUCERA, J;FAN, GP;ERNFORS, P
通讯作者：
ERNFORS, P