Association analysis of cigarette smoking with onset of primary open-angle glaucoma and glaucoma-related biometric parameters.
Association analysis of cigarette smoking with onset of primary open-angle glaucoma and glaucoma-related biometric parameters.
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吸烟与原发性开角型青光眼发病及青光眼相关生物特征参数的关联分析
DOI：
10.1186/1471-2415-12-59
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发表时间：
2012-11-27
影响因子：
2
通讯作者：
Zhang M
中科院分区：
文献类型：
--
作者：
Wang D;Huang Y;Huang C;Wu P;Lin J;Zheng Y;Peng Y;Liang Y;Chen JH;Zhang M
迄今为止，关于吸烟在原发性开角型青光眼（POAG）中的作用的研究仍存在争议。目前的研究评估了吸烟作为POAG的危险因素及其与垂直杯盘比（VCDR）、角膜中央厚度（CCT）和眼压（IOP）的关系。方法248例无关联人群，其中30例为青少年型POAG (JOAG)， 92例为成人型POAG (AOAG)， 126例为性别匹配的老年性白内障对照。通过问卷调查获得并记录了他们的吸烟情况。使用控制年龄和性别的logistic回归分析吸烟与POAG的关系。采用多元线性回归分析吸烟对VCDR、IOP和CCT的影响。结果在JOAG和AOAG中，吸烟与发病无相关性（P分别为0.692和0.925）。在对照组和JOAG中，吸烟对VCDR、IOP和CCT均无显著影响（p < 0.05）。吸烟与AOAG和合并POAG （JOAG + AOAG）患者CCT下降相关（P= 0.009和0.003），但与VCDR和IOP无相关性（P= 0.05）。结论吸烟虽不是POAG发病的危险因素，但与AOAG的CCT相关，可能在病程中发挥作用，尤其是AOAG。
BackgroundTo date, studies on the role played by cigarette smoking in primary open-angle glaucoma (POAG) remains controversial. The current study evaluated cigarette smoking as a risk factor of POAG and its relationships with vertical cup-to-disc ratio (VCDR), central corneal thickness (CCT) and intraocular pressure (IOP) in a Chinese cohort.MethodsIn a total of 248 unrelated individuals including 30 juvenile-onset POAG (JOAG), 92 adult-onset POAG (AOAG) and 126 sex-matched senile cataract controls, underwent comprehensive ophthalmic examination. Their smoking was obtained and documented by questionnaire. Association of cigarette smoking with POAG was performed using logistic regression controlled for age and sex. Effects of cigarette smoking on VCDR, IOP and CCT were analyzed with multiple linear regression.ResultsIn either JOAG or AOAG, no association of cigarette smoking was found with disease onset (P= 0.692 and 0.925 respectively). In controls and JOAG, no significant effects of smoking were found on VCDR, IOP or CCT (allP> 0.05). Smoking was found to be correlated with decreased CCT in AOAG and combined POAG (JOAG + AOAG) (P= 0.009 and 0.003), but no association with VCDR or IOP was observed (P> 0.05).ConclusionsAlthough cigarette smoking was not found to be risk factor for onset of POAG, it was correlated with CCT in AOAG, and thus might still play a role in the disease course, especially for AOAG.
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影响因子：
--
作者：
Kohlhaas, M;Boehm, AG;Pillunat, LE
通讯作者：
Pillunat, LE
影响因子：
5.2
作者：
Bonovas, S;Filioussi, K;Peponis, V
通讯作者：
Peponis, V
影响因子：
--
作者：
Kang, JH;Pasquale, LR;Hankinson, SE
通讯作者：
Hankinson, SE
DOI：
10.1007/s00417-009-1176-5
发表时间：
2010-04-01
影响因子：
2.7
作者：
Avitabile, Teresio;Longo, Antonio;Castaing, Marine
通讯作者：
Castaing, Marine
影响因子：
2
作者：
Lee, AJ;Rochtchina, E;Mitchell, P
通讯作者：
Mitchell, P