Role of extracellular matrix signaling cues in modulating cell fate commitment for cardiovascular tissue engineering.
Role of extracellular matrix signaling cues in modulating cell fate commitment for cardiovascular tissue engineering.
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DOI：
10.1002/adhm.201300620
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发表时间：
2014-05
影响因子：
10
通讯作者：
Huang NF
中科院分区：
文献类型：
--
作者：
Nakayama KH;Hou L;Huang NF
It is generally agreed that engineered cardiovascular tissues require cellular interactions with the local milieu. Within the microenvironment, the extracellular matrix (ECM) is an important support structure that provides dynamic signaling cues in part through its chemical, physical, and mechanical properties. In response to ECM factors, cells activate biochemical and mechanotransduction pathways that modulate their survival, growth, migration, differentiation, and function. This review describes the role of ECM chemical composition, spatial patterning, and mechanical stimulation in the specification of cardiovascular lineages, with a focus on stem cell differentiation, direct transdifferentiation, and endothelial-to-mesenchymal transition. The translational application of ECMs will be discussed in the context of cardiovascular tissue engineering and regenerative medicine.
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