Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects.
Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects.
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性别对瘦型非糖尿病受试者中胰岛素敏感性，肥胖和血浆脂质之间关系的影响。
DOI：
10.1016/j.metabol.2009.05.012
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发表时间：
2009-11
影响因子：
9.8
通讯作者：
Youngren, Jack F.
中科院分区：
文献类型：
--
作者：
Masharani, Umesh;Goldfine, Ira D.;Youngren, Jack F.
肥胖患者通常有致动脉粥样硬化的脂质特征。有人提出，在这些个体中观察到的胰岛素抵抗参与了这些脂质异常的发展。然而，大多数检查胰岛素抵抗和脂质异常之间关系的研究都包括肥胖和/或葡萄糖不耐受的受试者，这两个因素可能独立于胰岛素抵抗影响脂质水平。因此，我们在健康、精瘦（平均BMI < 24）、非糖尿病人群（n =104）中研究了胰岛素抵抗对血脂的影响。在我们的受试者中，我们观察到胰岛素敏感性指数值（ISI）的取值范围很广，由Matsuda和DeFronzo的公式计算。血脂值在这个人群中变化很大，但在没有肥胖的情况下，高甘油三酯血症和高胆固醇血症的发病率很低。我们首先通过双能x射线吸收仪（DXA）评估ISI与总脂肪和区域脂肪储存之间的关系。在男性中，我们观察到总脂肪和中心脂肪储存指数的较高值与胰岛素敏感性降低显著相关。相比之下，在女性中，ISI值与任何与整体或局部肥胖相关的变量无关。在男性中，ISI也与较高的甘油三酯水平显著相关（P < 0.01），当调整年龄和躯干脂肪百分比时。然而，在女性中，ISI和甘油三酯之间没有显著的关联（P = 0.14）。相反，在女性中，总脂肪和躯干脂肪是几种脂质水平的独立预测因子。这些结果都强调了胰岛素抵抗、区域脂肪储存和脂质值之间关系的性别差异，并强调了脂肪储存对个体脂质谱发展的重要性。
Individuals with obesity frequently have an atherogenic lipid profile. It has been proposed that the insulin resistance observed in these individuals is involved in the development of these lipid abnormalities. However, most studies that have examined the relationship between insulin resistance and lipid abnormalities have included subjects who are either obese and/or glucose intolerant, two factors that may affect lipid levels independent of insulin resistance. We have therefore examined the impact of insulin resistance on plasma lipids in a healthy, lean (average BMI < 24), non-diabetic population (n =104). In our subjects we observed a wide range of values for insulin sensitivity index values (ISI) as calculated by the formula of Matsuda and DeFronzo. Lipid values ranged considerably in this population, but incidence of hypertriglyceridemia and hypercholesterolemia were low in the absence of obesity. We first examined the relationship between ISI and total and regional adipose stores as assessed by dual-energy X-ray absorptiometry (DXA). In men, we observed higher values for indices of total and central adipose stores that were significantly associated with decreased insulin sensitivity. In contrast, in women, ISI values were not associated with any variables related to either total or regional adiposity. In men, ISI was also significantly associated with higher triglycerides levels (P < 0.01) when adjusted for age and percent truncal fat. In women however, there was no significant association between ISI and triglycerides (P = 0.14). Instead, in women, the total and truncal fat were independent predictors of several lipid levels. These results both highlight gender differences in the associations between insulin resistance, regional adipose stores and lipids values, and emphasize the importance of adipose stores on the development of an individual’s lipid profile.
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影响因子：
15.9
作者：
REAVEN, GM;CHEN, YDI;KRAUSS, RM
通讯作者：
KRAUSS, RM
影响因子：
7.7
作者：
Meigs, JB;DAgostino, RB;Singer, DE
通讯作者：
Singer, DE
DOI：
10.1161/01.atv.12.9.1030
发表时间：
1992-09-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
GODSLAND, IF;CROOK, D;OLIVER, MF
通讯作者：
OLIVER, MF
影响因子：
7.1
作者：
NEWELLMORRIS, LL;TREDER, RP;FUJIMOTO, WY
通讯作者：
FUJIMOTO, WY
影响因子：
9.8
作者：
Phillips, DIW;Caddy, S;Taylor, R
通讯作者：
Taylor, R