Occasion setting by drug states: Functional equivalence following similar training history.
Occasion setting by drug states: Functional equivalence following similar training history.
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DOI：
10.1016/j.bbr.2008.09.009
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发表时间：
2008-12-22
影响因子：
2.7
通讯作者：
Bevins, Rick A.
中科院分区：
文献类型：
--
作者：
Palmatier, Matthew I.;Bevins, Rick A.
三个实验研究是否药物状态作为一个积极的功能之间的配对离散的条件刺激（CS，15-S光或15-S噪音）和蔗糖可以转移促进控制CS，它从来没有提出。为此，在尼古丁（0.4 mg/kg）、安非他明（AMP，1 mg/kg）或利血平（CDP，5 mg/kg）药物状态下，将CS与蔗糖奖励配对;在单独的生理盐水治疗中，提供CS，但随后不提供任何奖励。所有三种药物状态促进响应离散CS;以前的研究发现，这种促进作用并不依赖于药物状态和蔗糖之间的直接关联。当训练第二个辨别时（例如，CDP：轻蔗糖和尼古丁：噪声-蔗糖）的药物状态促进对在该状态（尼古丁：噪声）中训练的CS以及在其他药物状态（例如，尼古丁：轻）。一种新的药物状态（例如，安非他明）不影响对任一CS的反应，表明最初训练的药物状态基于学习历史获得了功能相似性。此外，一个新的或模糊的CS没有引起响应在以前训练的药物状态，表明这两个功能（药物状态）和目标条件刺激必须在转移之前进行训练的歧视可能发生。
Three experiments examined whether a drug state serving as a positive feature for pairings between a discrete conditional stimulus (CS, 15-s light or 15-s noise) and sucrose could transfer facilitative control to a CS with which it had never been presented. To do so, a CS was paired with a sucrose reward in the nicotine (0.4 mg/kg), amphetamine (AMP, 1 mg/kg), or chlordiazepoxide (CDP, 5 mg/kg) drug state; in separate saline sessions the CS was presented but was not followed by any reward. All three drug states facilitated responding to a discrete CS; previous studies found that this facilitation did not depend on direct associations between the drug state and sucrose. When a second discrimination was trained (e.g., CDP: light-sucrose and nicotine: noise-sucrose) the drug states facilitated responding to the CS trained in that state (nicotine: noise) as well as the CS normally presented in the other drug state (e.g., nicotine: light). A novel drug state (e.g., amphetamine) did not affect responding to either CS, indicating that the originally trained drug states had acquired functional similarity based on learning history. Also, a novel or ambiguous CS did not evoke responding in the previously trained drug state, indicating that both the features (drug states) and target conditional stimuli had to be trained in discriminations before transfer could occur.
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影响因子：
3.6
作者：
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通讯作者：
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