Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance.
Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance.
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DOI：
10.1038/s41598-021-84503-3
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发表时间：
2021-03-03
影响因子：
4.6
通讯作者：
Grill WM
中科院分区：
文献类型：
--
作者：
Peña E;Pelot NA;Grill WM
使用千赫兹频率电信号的神经传导的可逆阻断具有治疗疾病的巨大潜力。然而，选择性地阻断神经纤维的能力受到对波形参数与被阻断的神经纤维之间的关系的理解不足的限制。先前的体内研究报告了阻滞信号频率和阻滞阈值之间的非单调关系，表明可能存在纤维选择性阻滞。然而，非单调性阻滞阈值的机制尚不清楚，这些发现在随后的体内研究中没有重复。我们使用高保真计算模型和在麻醉大鼠体内的实验表明，非单调的阈值频率的关系确实发生，它们是由幅度和频率依赖性的电荷不平衡，导致千赫频率和直流阻断制度之间的转变，这些关系可以不同的纤维直径，使较小的纤维可以被阻止在较低的阈值比较大的纤维。这些结果调和以前的矛盾研究，澄清千赫兹频率和直流块之间的相互作用的机制，并展示了小纤维直径的选择性块的潜力。
Reversible block of nerve conduction using kilohertz frequency electrical signals has substantial potential for treatment of disease. However, the ability to block nerve fibers selectively is limited by poor understanding of the relationship between waveform parameters and the nerve fibers that are blocked. Previous in vivo studies reported non-monotonic relationships between block signal frequency and block threshold, suggesting the potential for fiber-selective block. However, the mechanisms of non-monotonic block thresholds were unclear, and these findings were not replicated in a subsequent in vivo study. We used high-fidelity computational models and in vivo experiments in anesthetized rats to show that non-monotonic threshold-frequency relationships do occur, that they result from amplitude- and frequency-dependent charge imbalances that cause a shift between kilohertz frequency and direct current block regimes, and that these relationships can differ across fiber diameters such that smaller fibers can be blocked at lower thresholds than larger fibers. These results reconcile previous contradictory studies, clarify the mechanisms of interaction between kilohertz frequency and direct current block, and demonstrate the potential for selective block of small fiber diameters.
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DOI：
10.1111/ner.12100
发表时间：
2014-04
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Kilgore KL;Bhadra N
通讯作者：
Bhadra N
影响因子：
3
作者：
Franke, Manfred;Bhadra, Niloy;Bhadra, Narendra;Kilgore, Kevin
通讯作者：
Kilgore, Kevin
影响因子：
4
作者：
Ackermann DM;Bhadra N;Gerges M;Thomas PJ
通讯作者：
Thomas PJ
影响因子：
3.4
作者：
Bhadra, N;Kilgore, KL
通讯作者：
Kilgore, KL
影响因子：
5.5
作者：
HAYDON, DA;URBAN, BW
通讯作者：
URBAN, BW