Direct current contamination of kilohertz frequency alternating current waveforms.
Direct current contamination of kilohertz frequency alternating current waveforms.
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DOI：
10.1016/j.jneumeth.2014.04.002
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发表时间：
2014-07-30
影响因子：
3
通讯作者：
Kilgore, Kevin
中科院分区：
文献类型：
--
作者：
Franke, Manfred;Bhadra, Niloy;Bhadra, Narendra;Kilgore, Kevin
千赫兹频率交流电（KHFAC）波形正在各种生理环境中进行评估，因为与亚千赫兹范围内的频率相比，它们具有独特的调节神经活动的潜力。然而，在该频率范围内使用波形对发生器输出提出了一些独特的挑战。在这项研究中，我们探讨了直流电（DC）的KHFAC波形的不良污染的可能性。我们评估了电流和电压控制的KHFAC波形发生器的配置，包括发生器和电极之间的电容耦合，电阻耦合和电容与电感耦合的组合。我们的研究结果表明，电压和电流控制的信号发生器可以无意中添加直流污染的KHFAC信号，电容耦合并不总是足以消除这种污染。我们还证明了与电极并联放置的高值电感器可以有效消除DC污染，无论刺激器的类型如何，将DC污染降低到小于1 μA。这项研究强调了仔细设计KHFAC研究中使用的电子设置的重要性，并建议在评估KHFAC波形神经反应的所有研究中进行和报告的特定测试。
Kilohertz Frequency Alternating Current (KHFAC) waveforms are being evaluated in a variety of physiological settings because of their potential to modulate neural activity uniquely when compared to frequencies in the sub-kilohertz range. However, the use of waveforms in this frequency range presents some unique challenges regarding the generator output. In this study we explored the possibility of undesirable contamination of the KHFAC waveforms by direct current (DC). We evaluated current- and voltage-controlled KHFAC waveform generators in configurations that included a capacitive coupling between generator and electrode, a resistive coupling and combinations of capacitive with inductive coupling. Our results demonstrate that both voltage- and current-controlled signal generators can unintentionally add DC-contamination to a KHFAC signal, and that capacitive coupling is not always sufficient to eliminate this contamination. We furthermore demonstrated that high value inductors, placed in parallel with the electrode, can be effective in eliminating DC-contamination irrespective of the type of stimulator, reducing the DC contamination to less than 1 μA. This study highlights the importance of carefully designing the electronic setup used in KHFAC studies and suggests specific testing that should be performed and reported in all studies that assess the neural response to KHFAC waveforms.
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DOI：
10.1111/ner.12100
发表时间：
2014-04
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Kilgore KL;Bhadra N
通讯作者：
Bhadra N
影响因子：
2.8
作者：
Tiede, Jeffrey;Brown, Lora;Morgan, Donna
通讯作者：
Morgan, Donna
影响因子：
4.6
作者：
NAPLES, GG;MORTIMER, JT;SWEENEY, JD
通讯作者：
SWEENEY, JD
影响因子：
3.4
作者：
Bhadra, N;Kilgore, KL
通讯作者：
Kilgore, KL
影响因子：
1.4
作者：
SHEPHERD, RK;MATSUSHIMA, J;CLARK, GM
通讯作者：
CLARK, GM