Toxicity and developmental defects of different sizes and shape nickel nanoparticles in zebrafish.
Toxicity and developmental defects of different sizes and shape nickel nanoparticles in zebrafish.
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DOI：
10.1021/es9010543
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发表时间：
2009-08-15
影响因子：
11.4
通讯作者：
Wallace, Kenneth N.
中科院分区：
文献类型：
--
作者：
Ispas, Cristina;Andreescu, Daniel;Patel, Avni;Goia, Dan V.;Andreescu, Silvana;Wallace, Kenneth N.
镍等金属纳米颗粒用于催化、传感和电子应用，但对健康和环境的影响尚未得到充分研究。虽然一些金属纳米颗粒会导致毒性，但确定相同金属但不同尺寸和形状的纳米颗粒是否会改变毒性也很重要。合成了三种不同尺寸的镍纳米颗粒（Ni NPs），分别为30、60和100 nm，以及具有树枝状结构的聚集60 nm实体的更大颗粒簇，并将其暴露于斑马鱼胚胎中，以评估死亡率和发育缺陷。将Ni NP暴露与可溶性镍盐进行比较。所有三种30、60和100 nm Ni NP的毒性等于或小于可溶性镍，而树枝状簇的毒性更大。随着每次Ni NP暴露，肠上皮的变薄首先发生在LD 10附近，持续到LD 50。LD50暴露也导致骨骼肌纤维分离。暴露于可溶性镍不会导致肠道缺陷，而骨骼肌分离发生在浓度远远超过LD 50。这些结果表明，纳米颗粒的配置可能会影响毒性比尺寸和缺陷从镍纳米颗粒暴露发生不同的生物机制比可溶性镍。
Metallic nanoparticles such as nickel are used in catalytic, sensing and electronic applications, but health and environmental affects have not been fully investigated. While some metal nanoparticles result in toxicity, it is also important to determine whether nanoparticles of the same metal but of different size and shape changes toxicity. Three different size nickel nanoparticle (Ni NPs) of 30, 60, and 100 nm and larger particle clusters of aggregated 60 nm entities with a dendritic structure were synthesized and exposed to zebrafish embryos assessing mortality and developmental defects. Ni NPs exposure was compared to soluble nickel salts. All three 30, 60, and 100 nm Ni NPs are equal to or less toxic than soluble nickel while dendritic clusters were more toxic. With each Ni NP exposure, thinning of the intestinal epithelium first occurs around the LD10 continuing into the LD50. LD50 exposure also results in skeletal muscle fiber separation. Exposure to soluble nickel does not cause intestinal defects while skeletal muscle separation occurs at concentrations well over LD50. These results suggest that configuration of nanoparticles may affect toxicity more than size and defects from Ni NPs exposure occur by different biological mechanisms than soluble nickel.
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影响因子：
--
作者：
HUMPHREY, CD;PITTMAN, FE
通讯作者：
PITTMAN, FE
影响因子：
17.1
作者：
Lee, Kerry J.;Nallathamby, Prakash D.;Xu, Xiao-Hong Nancy
通讯作者：
Xu, Xiao-Hong Nancy
影响因子：
4.1
作者：
Griffitt, Robert J.;Luo, Jing;Barber, David S.
通讯作者：
Barber, David S.
功能化镍纳米颗粒对白血病癌细胞的体外细胞摄取和细胞毒作用。
影响因子：
--
作者：
Guo, Dadong;Wu, Chunhui;Chen, Baoan
通讯作者：
Chen, Baoan
影响因子：
3.2
作者：
Khan, Jameel Ahmad;Pillai, Beena;Maiti, Souvik
通讯作者：
Maiti, Souvik