Objective analyses of tessellated fundi and significant correlation between degree of tessellation and choroidal thickness in healthy eyes.
Objective analyses of tessellated fundi and significant correlation between degree of tessellation and choroidal thickness in healthy eyes.
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DOI：
10.1371/journal.pone.0103586
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Sakamoto T
中科院分区：
文献类型：
--
作者：
Yoshihara N;Yamashita T;Ohno-Matsui K;Sakamoto T
棋盘状眼底是近视眼的常见特征，也是视网膜脉络膜变化的重要临床标志。然而，棋盘状眼底的确切原因和意义尚未明确确定。我们客观地确定了正常、非病理性近视眼眼底的镶嵌程度，并将镶嵌程度与脉络膜厚度 (CT) 和眼轴长度 (AL) 相关联。这是一项前瞻性观察横断面研究。根据检眼镜观察到的镶嵌程度，将眼睛主观分为三组。通过图像处理程序 ImageJ 评估数字彩色眼底照片的镶嵌程度。计算了三个镶嵌的眼底指数（TFI）并与三个主观确定的组进行比较。在光学相干断层扫描图像中测量中心凹下和鼻部 CT。计算 TFI 和 CT 之间的相关性。此外，还计算了 TFI 和 AL 之间的相关性。研究人员对 100 名健康志愿者（平均年龄 25.8±3.9 岁）的 100 只右眼进行了研究。通过检眼镜检查，57只眼睛被放置在非镶嵌组中，27只眼睛被放置在弱镶嵌组中，16只眼睛被放置在强镶嵌组中。主观分类与TFI值之间存在显着相关性（P<0.05，Kruskal-Wallis检验）。所有TFI均与中心凹下和鼻腔CT显着相关（R = −0.20至−0.24，P<0.05）。 TFI 与 AL 不显着相关。总之，镶嵌程度的主观和客观分类之间的显着相关性表明TFI可以用于对镶嵌程度进行分类。结果表明 CT 的差异说明了镶嵌程度。
A tessellated fundus is a common characteristic of myopic eyes and is an important clinical marker for the development of retinochoroidal changes. However, the exact cause and significance of tessellated fundi have not been definitively determined. We determined the degree of tessellation in fundi objectively in normal, non-pathological myopic eyes, and correlated the degree of tessellation and the choroidal thickness (CT) and axial length (AL). This was a prospective observational cross sectional study. The eyes were classified subjectively into three groups based on the degree of tessellation observed ophthalmoscopically. Digital color fundus photographs were assessed for the degree of tessellation by ImageJ, an image processing program. Three tessellated fundus indices (TFIs) were calculated and were compared to the three subjectively-determined groups. The subfoveal and nasal CTs were measured in the optical coherence tomographic images. The correlations between the TFIs and the CT were calculated. Additionally, the correlation between the TFIs and the AL was calculated. One hundred right eyes of 100 healthy volunteers (mean age 25.8±3.9 years) were studied. Ophthalmoscopically, 57 eyes were placed in the non-tessellated group, 27 eyes into the weakly tessellated group, and 16 eyes into the strongly tessellated group. There was a significant correlation between the subjective classifications and the TFI values (P<0.05, Kruskal-Wallis test). All of the TFIs were significantly associated with the subfoveal and nasal CT (R = −0.20 to −0.24, P<0.05). The TFIs were not significantly correlated with the ALs. In conclusion, the significant correlation between the subjective and objective classifications of the degree of tessellation indicates that TFIs can be used to classify the degree of tessellation. The results indicate that the differences in the CT account for the degree of tessellation.
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