Sex Differences in Protein Expression and Their Perturbations in Amniotic Fluid Cells of Down Syndrome Fetuses.
Sex Differences in Protein Expression and Their Perturbations in Amniotic Fluid Cells of Down Syndrome Fetuses.
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DOI：
10.1021/acsomega.2c05152
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发表时间：
2022-10-11
期刊：
影响因子：
4.1
通讯作者：
Sun, Huaqin
中科院分区：
文献类型：
--
作者：
Liu, Yanyan;Zhang, Xuan;Zhang, Lili;Zhu, Hongmei;Chen, Jiurong;Lin, Ziyuan;Zhou, Bin;Liu, Shanling;Wang, He;Sun, Huaqin
唐氏综合征（DS）是最常见的与智力残疾相关的染色体疾病，其特征是各种其他临床表现。DS的发病机制和性别差异尚不清楚。为了鉴定可能作为潜在生物学标志物的差异表达蛋白，阐明T21胎儿不同性别之间发病机制的差异，为个体化检测和治疗提供线索是必要的。通过羊膜穿刺术采集T21雄性、T21雌性、CN雄性和CN雌性的羊膜细胞样本。通过质谱法定量分析，确定对应于各样品的肽的定量值。我们鉴定了T21胎儿和CN胎儿/T21雄性和CN雄性/T21雌性和CN雌性/以及T21雄性和T21雌性之间的许多差异表达蛋白。这些差异蛋白与许多重要的生物过程相关，并影响多个系统的发育，包括心脏，造血，免疫，生殖和神经系统。我们的研究结果表明，性别特异性的蛋白质表达和生物学过程的调制，并提供了新的见解性别特异性差异的发病机制的DS。
Down syndrome (DS) is the most common chromosomal condition associated with intellectual disability and is characterized by a variety of additional clinical findings. The pathogenesis of DS and the differences between the sexes are not clear. In order to identify differentially expressed proteins that might be employed as potential biological markers and elucidate the difference in pathogenesis between different genders of T21 fetuses, providing clues for individualized detection and treatment is essential. Amniocyte samples of T21 males, T21 females, CN males, and CN females were collected by amniocentesis. The quantitative value of the peptide corresponding to each sample was determined through quantitative analysis by mass spectrometry. We identified many differentially expressed proteins between T21 fetuses and CN fetuses/T21 males and CN males/T21 females and CN females/and T21 males and T21 females. These differential proteins are associated with many important biological processes and affect the development of multiple systems, including the heart, hematopoietic, immune, reproductive, and nervous systems. Our results show sex-specific modulation of protein expression and biological processes and provide new insights into sex-specific differences in the pathogenesis of DS.
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影响因子：
64.8
作者：
Zhao, Ruozhu;Chen, Xin;Qi, Hai
通讯作者：
Qi, Hai
影响因子：
14.9
作者：
Ma J;Chen T;Wu S;Yang C;Bai M;Shu K;Li K;Zhang G;Jin Z;He F;Hermjakob H;Zhu Y
通讯作者：
Zhu Y
DOI：
10.1038/s41582-018-0132-6
发表时间：
2019-03
期刊：
Nature reviews. Neurology
影响因子：
--
作者：
Lott IT;Head E
通讯作者：
Head E
影响因子：
3.3
作者：
Chen, Chih-Ping;Lai, Tzu-Chia;Chan, Hong-Lin
通讯作者：
Chan, Hong-Lin
影响因子：
5.6
作者：
Rozmus D;Ciesielska A;Płomiński J;Grzybowski R;Fiedorowicz E;Kordulewska N;Savelkoul H;Kostyra E;Cieślińska A
通讯作者：
Cieślińska A