Skeletal muscle as a regulator of the longevity protein, Klotho.
Skeletal muscle as a regulator of the longevity protein, Klotho.
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DOI：
10.3389/fphys.2014.00189
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发表时间：
2014
影响因子：
4
通讯作者：
Ambrosio F
中科院分区：
文献类型：
--
作者：
Avin KG;Coen PM;Huang W;Stolz DB;Sowa GA;Dubé JJ;Goodpaster BH;O'Doherty RM;Ambrosio F
Klotho是一种强大的长寿蛋白，与预防肌肉萎缩，骨质疏松和心血管疾病有关。类似的抗衰老效果也被归因于运动和体育活动。虽然肌肉功能和Klotho表达之间的关联先前已从纵向队列研究中提出，但尚未研究循环Klotho和骨骼肌之间的直接关系。在本文中，我们提出了一个文献综述和初步证据，一起，表明Klotho表达可能是由骨骼肌活动调制。我们在年轻人和老年人中进行的试点临床研究结果表明，循环Klotho水平在急性运动回合中上调，但该反应可能取决于健身水平。在年轻和老年小鼠中，也观察到循环Klotho响应于急性运动的类似上调，这表明这可能是机械地探索身体活动对Klotho表达的作用的良好模型。最后，我们强调重叠的信号通路，由Klotho和骨骼肌调制，并提出了潜在的机制，两者之间的串扰。希望这篇综述将刺激进一步考虑骨骼肌活动和Klotho表达之间的关系，可能导致对运动的系统性抗衰老作用的重要见解。
Klotho is a powerful longevity protein that has been linked to the prevention of muscle atrophy, osteopenia, and cardiovascular disease. Similar anti-aging effects have also been ascribed to exercise and physical activity. While an association between muscle function and Klotho expression has been previously suggested from longitudinal cohort studies, a direct relationship between circulating Klotho and skeletal muscle has not been investigated. In this paper, we present a review of the literature and preliminary evidence that, together, suggests Klotho expression may be modulated by skeletal muscle activity. Our pilot clinical findings performed in young and aged individuals suggest that circulating Klotho levels are upregulated in response to an acute exercise bout, but that the response may be dependent on fitness level. A similar upregulation of circulating Klotho is also observed in response to an acute exercise in young and old mice, suggesting that this may be a good model for mechanistically probing the role of physical activity on Klotho expression. Finally, we highlight overlapping signaling pathways that are modulated by both Klotho and skeletal muscle and propose potential mechanisms for cross-talk between the two. It is hoped that this review will stimulate further consideration of the relationship between skeletal muscle activity and Klotho expression, potentially leading to important insights into the well-documented systemic anti-aging effects of exercise.
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影响因子：
11.1
作者：
Carlson, Morgan E.;Suetta, Charlotte;Conboy, Michael J.;Aagaard, Per;Mackey, Abigail;Kjaer, Michael;Conboy, Irina
通讯作者：
Conboy, Irina
影响因子：
24
作者：
Chomistek, Andrea K.;Manson, JoAnn E.;Stefanick, Marcia L.;Lu, Bing;Sands-Lincoln, Megan;Going, Scott B.;Garcia, Lorena;Allison, Matthew A.;Sims, Stacy T.;LaMonte, Michael J.;Johnson, Karen C.;Eaton, Charles B.
通讯作者：
Eaton, Charles B.
影响因子：
--
作者：
Chang, JT;Morton, SC;Shekelle, PG
通讯作者：
Shekelle, PG
影响因子：
7.4
作者：
Gomez-Cabrera, Mari-Carmen;Domenech, Elena;Vina, Jose
通讯作者：
Vina, Jose
影响因子：
64.8
作者：
Conboy, IM;Conboy, MJ;Rando, TA
通讯作者：
Rando, TA