Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling.
Chinese Herbal Formula Huo-Luo-Xiao-Ling Dan Protects against Bone Damage in Adjuvant Arthritis by Modulating the Mediators of Bone Remodeling.
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DOI：
10.1155/2013/429606
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Moudgil KD
中科院分区：
文献类型：
--
作者：
Nanjundaiah SM;Lee DY;Berman BM;Moudgil KD
活络消灵丹(HLXL)是一种中药混合物，长期以来一直被用于治疗类风湿性关节炎(RA)和其他炎症性疾病。尽管目前已有治疗类风湿性关节炎的有效药物，但其在部分患者中的疗效有限，再加上其高昂的成本和严重的不良反应，因此有必要寻找新的治疗方法来治疗这种令人衰弱的疾病。此外，控制炎症和骨损伤对于有效治疗关节炎至关重要。本研究的目的是评价和龙血灵对佐剂性关节炎(AA)模型大鼠关节炎骨损伤的治疗作用。我们的结果表明，HLXL治疗能抑制关节炎Lewis大鼠关节的炎性关节炎，减轻骨和软骨的损伤。HLXL诱导的骨损伤保护作用主要通过抑制破骨细胞性骨重建的介质(如核因子-kappa-B受体激活剂，RANKL)，改变RANKL/OPG的比值，有利于抗破骨细胞活性，减少关节骨中破骨细胞的数量，以及抑制细胞因子的产生和基质金属蛋白酶的活性来实现。我们的结果表明，HLXL可能为RA的炎症和骨损伤提供一种有前途的替代/辅助治疗。
Huo-luo-xiao-ling dan (HLXL) is an herbal mixture that has long been used in traditional Chinese medicine for the treatment of rheumatoid arthritis (RA) and other inflammatory disorders. Despite the availability of potent conventionally used drugs for RA, their limited efficacy in a proportion of patients coupled with their high cost and severe adverse effects has necessitated the search for novel therapeutics for this debilitating disease. Further, the control of both inflammation and bone damage is essential for effective management of arthritis. The aim of our study was to evaluate the efficacy of HLXL against arthritic bone damage in adjuvant arthritis (AA) model of RA. Our results show that HLXL treatment suppressed inflammatory arthritis and reduced bone and cartilage damage in the joints of arthritic Lewis rats. HLXL-induced protection against bone damage was mediated primarily via inhibition of mediators of osteoclastic bone remodeling (e.g., receptor activator of nuclear factor kappa-B ligand; RANKL), skewing of RANKL/osteoprotegerin (OPG) ratio in favor of antiosteoclastic activity, reduction in the number of osteoclasts in the arthrodial joint's bone, and inhibition of cytokine production and MMP activity. Our results suggest that HLXL might offer a promising alternative/adjunct treatment for both inflammation and bone damage in RA.
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DOI：
10.1093/ecam/nel105
发表时间：
2007-12
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Hijikata Y;Miyamae Y;Takatsu H;Sentoh S
通讯作者：
Sentoh S
影响因子：
27.4
作者：
Jones, DH;Kong, YY;Penninger, JM
通讯作者：
Penninger, JM
影响因子：
4.8
作者：
HILL, PA;REYNOLDS, JJ;MEIKLE, MC
通讯作者：
MEIKLE, MC
影响因子：
7.2
作者：
Komeh-Nkrumah, Steva A.;Nanjundaiah, Siddaraju M.;Moudgil, Kamal D.
通讯作者：
Moudgil, Kamal D.
影响因子：
10.5
作者：
Dougall, WC;Glaccum, M;Schuh, J
通讯作者：
Schuh, J