Techniques for physicochemical characterization of nanomaterials.
Techniques for physicochemical characterization of nanomaterials.
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DOI：
10.1016/j.biotechadv.2013.11.006
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发表时间：
2014-07
影响因子：
16
通讯作者：
Sridhar, Rajagopalan
中科院分区：
文献类型：
--
作者：
Lin, Ping-Chang;Lin, Stephen;Wang, Paul C.;Sridhar, Rajagopalan
纳米技术的进步开辟了一个诊断、预防和治疗疾病和创伤的新时代。纳米材料，包括那些具有临床应用潜力的纳米材料，具有从分子水平到系统水平对其生理相互作用产生影响的新型物理化学性质。目前还缺乏检测或表征纳米材料的标准化方法或监管方案。本文综述了纳米材料的尺寸、形状、表面性质、组成、纯度和稳定性研究的常用技术，以及它们的优缺点。目前，FDA还没有专门为诊断或治疗用途的纳米材料配方制定指南。目前迫切需要标准化的方案和程序来表征纳米颗粒，特别是那些用于治疗的纳米颗粒。
Advances in nanotechnology have opened up a new era of diagnosis, prevention and treatment of diseases and traumatic injuries. Nanomaterials, including those with potential for clinical applications, possess novel physicochemical properties that have an impact on their physiological interactions, from the molecular level to the systemic level. There is a lack of standardized methodologies or regulatory protocols for detection or characterization of nanomaterials. This review summarizes the techniques that are commonly used to study the size, shape, surface properties, composition, purity and stability of nanomaterials, along with their advantages and disadvantages. At present there are no FDA guidelines that have been developed specifically for nanomaterial based formulations for diagnostic or therapeutic use. There is an urgent need for standardized protocols and procedures for the characterization of nanoparticles, especially those that are intended for use as theranostics.
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影响因子：
3.2
作者：
ALBRECHT, TR;DOVEK, MM;PEASE, RFW
通讯作者：
PEASE, RFW
影响因子：
5.2
作者：
Brown, Scott C.;Kamal, Mohammed;Moudgil, Brij M.
通讯作者：
Moudgil, Brij M.
影响因子：
17.1
作者：
Asati A;Santra S;Kaittanis C;Perez JM
通讯作者：
Perez JM
影响因子：
10.2
作者：
Bothun GD
通讯作者：
Bothun GD
影响因子：
--
作者：
AVOURIS, P
通讯作者：
AVOURIS, P