Concerted transpositions of mobile genetic elements coupled with fitness changes in Drosophila melanogaster.

Concerted transpositions of mobile genetic elements coupled with fitness changes in Drosophila melanogaster.
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移动遗传元件的协调转位与果蝇适应性变化相结合。

DOI:
10.1093/oxfordjournals.molbev.a040398
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发表时间:
1986
影响因子:
10.7
通讯作者:
V. Gvozdev
V. Gvozdev
中科院分区:
生物学1区
文献类型:
--
作者:
E. Pasyukova;E. Belyaeva;G. Kogan;L. Kaidanov;V. Gvozdev

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在低适应度和不适应性状复合体的黑腹果蝇(Drosophila melanogaster)低活性(low-activity, LA)自交系中,原位杂交显示了3个拷贝样元件(mdg-1、mdg-3和拷贝)的不变分布模式。在LA菌株中,罕见的、自发的、可移动元素的多次转位被证明与适应度的急剧增加相结合。在选择适合度较高的LA品系时,也观察到不同类型的可移动元素的变化模式。高适应度菌株显示移动元件转位到特定的染色体位点(“热点”)。研究发现,三种不同移动元素位置的一致变化与健康水平的提高相结合。从高适应度菌株中独立选择两个低适应度菌株,研究了mdg-1的分布模式。适应度降低伴随着mdg-1从高适应度品系通常检测到的热点位置切除。结果表明,存在一个参与适应度控制的可移动元素自适应转位系统。
In an inbred low-activity (LA) strain of Drosophila melanogaster with a low level of fitness and a complex of inadaptive characters, in situ hybridization reveals an invariant pattern of distribution of three copia-like elements (mdg-1, mdg-3, and copia). Rare, spontaneous, multiple transpositions of mobile elements in the LA strain were shown to be coupled with a drastic increase of fitness. A changed pattern of various types of mobile elements was also observed on selecting the LA strain for higher fitness. High-fitness strains show transpositions of mobile elements to definite chromosomal sites ("hot spots"). Concerted changes in the location of three different mobile elements were found to be coupled with an increase of fitness. The mdg-1 distribution patterns were also examined in two low-fitness strains independently selected from the high-fitness ones. Fitness decrease was accompanied by mdg-1 excision from the hot spots of their location usually detected in the high-fitness strains. The results suggest the existence of a system of adaptive transpositions of mobile elements that takes part in fitness control.
非 Alu 家族散布在人类 DNA 中的重复序列及其转录活性。
DOI: 10.1093/nar/12.6.2669
发表时间: 1984
影响因子: 14.9
作者:
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通讯作者: Leinwand,L
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发表时间: 1981
期刊: Biochemistry
影响因子: 2.9
作者:
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DOI: 10.1016/0022-2836(81)90219-9
发表时间: 1981-01-01
影响因子: 5.6
作者:
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通讯作者: SCHMID, CW
人科灵长类动物的系统发育:DNA-DNA 杂交数据的统计分析。
DOI: 10.1093/oxfordjournals.molbev.a040363
发表时间: 1985
影响因子: 10.7
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Templeton,AR
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DOI: 10.1089/dna.1985.4.1
发表时间: 1985
期刊: DNA (Mary Ann Liebert, Inc.)
影响因子: --
作者:
Maurer,RA
通讯作者: Maurer,RA