Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division.
Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division.
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DOI：
10.1038/nn.3815
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发表时间：
2014-11
影响因子：
25
通讯作者：
Nishiyama, Akiko
中科院分区：
文献类型：
--
作者：
Hill, Robert A.;Patel, Kiran D.;Goncalves, Christopher M.;Grutzendler, Jaime;Nishiyama, Akiko
哺乳动物大脑中的少突胶质细胞在整个出生后生命中不断地从NG 2细胞产生。然而，NG 2细胞在细胞分裂后何时决定自我更新或分化为少突胶质细胞仍不清楚。使用固定组织中增殖的NG 2细胞的体内和离体成像和命运分析的组合，我们证明了在出生后发育的小鼠脑中，大多数分裂的NG 2细胞在3-8天的关键年龄特异性时间窗期间分化为少突胶质细胞。重要的是，在这段时间内，髓鞘和少突胶质细胞损伤加速少突胶质细胞分化的分裂细胞，而胡须去除减少了剥夺体感皮层中的分裂细胞的存活。这些研究结果表明，在可塑性的关键时间窗口，分裂的NG 2细胞的命运是敏感的外部信号调制。
Oligodendrocytes in the mammalian brain are continuously generated from NG2 cells throughout postnatal life. However it has remained unclear when the decision of NG2 cells to self-renew or differentiate into oligodendrocytes occurs after cell division. Using a combination of in vivo and ex vivo imaging and fate analysis of proliferated NG2 cells in fixed tissue, we demonstrate that in the postnatal developing mouse brain, the majority of divided NG2 cells differentiate into oligodendrocytes during a critical age-specific temporal window of 3–8 days. Importantly, within this time period, myelin and oligodendrocyte damage accelerated oligodendrocyte differentiation from divided cells, while whisker removal decreased the survival of divided cells in the deprived somatosensory cortex. These findings indicate that during the critical temporal window of plasticity, the fate of divided NG2 cells is sensitive to modulation by external signals.
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影响因子：
16.2
作者：
Kang, Shin H.;Fukaya, Masahiro;Yang, Jason K.;Rothstein, Jeffrey D.;Bergles, Dwight E.
通讯作者：
Bergles, Dwight E.
影响因子：
6.2
作者：
Bu, J;Banki, A;Nishiyama, A
通讯作者：
Nishiyama, A
影响因子：
3.5
作者：
Dawson, MRL;Polito, A;Reynolds, R
通讯作者：
Reynolds, R
DOI：
10.1083/jcb.200905111
发表时间：
2010-02-08
期刊：
The Journal of cell biology
影响因子：
--
作者：
Chong SY;Chan JR
通讯作者：
Chan JR
DOI：
10.1126/science.1220845
发表时间：
2012-09-14
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Makinodan M;Rosen KM;Ito S;Corfas G
通讯作者：
Corfas G