Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties.
Numerical model of optical coherence tomographic vibrography imaging to estimate corneal biomechanical properties.
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DOI：
10.1098/rsif.2014.0920
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发表时间：
2014-12-06
期刊：
影响因子：
--
通讯作者：
Marcos S
中科院分区：
文献类型：
--
作者：
Kling S;Akca IB;Chang EW;Scarcelli G;Bekesi N;Yun SH;Marcos S
大多数在体内测量角膜生物力学的技术都受到一些次要因素的影响。我们展示了光学相干层析成像（OCT）振动成像确定角膜材料参数的能力，同时减少了目前其他技术（如眼压（IOP）和厚度依赖）的普遍限制。在有限元（FE）模型中进行模态分析，研究孤立薄角膜瓣/眼球的振荡响应，并分析频率响应函数与角膜弹性、粘弹性、几何形状（厚度和曲率）、IOP和密度的依赖关系。利用声激励（100-110 dB）和相敏OCT测量频率响应函数（范围50-510 Hz），在三个牛角膜和两个去核猪眼的皮瓣上验证了该模型。仿真结果表明，皮瓣的角膜振动对几何参数和生物力学参数都敏感，而整个球体的角膜振动主要对角膜生物力学参数敏感。基于固有频移的计算表明，后角膜瓣的硬度比前角膜瓣的硬度低0.8倍，交联角膜的硬度比原始角膜的硬度低1.6倍。灵敏度分析表明，在生理范围内，整个球体的固有振动频率与角膜厚度和IOP几乎无关。OCT振动成像是一种很有前途的无创角膜弹性测量技术，不受角膜厚度和眼压的影响。
Most techniques measuring corneal biomechanics in vivo are biased by side factors. We demonstrate the ability of optical coherence tomographic (OCT) vibrography to determine corneal material parameters, while reducing current prevalent restrictions of other techniques (such as intraocular pressure (IOP) and thickness dependency). Modal analysis was performed in a finite-element (FE) model to study the oscillation response in isolated thin corneal flaps/eye globes and to analyse the dependency of the frequency response function on: corneal elasticity, viscoelasticity, geometry (thickness and curvature), IOP and density. The model was verified experimentally in flaps from three bovine corneas and in two enucleated porcine eyes using sound excitation (100–110 dB) together with a phase-sensitive OCT to measure the frequency response function (range 50–510 Hz). Simulations showed that corneal vibration in flaps is sensitive to both, geometrical and biomechanical parameters, whereas in whole globes it is primarily sensitive to corneal biomechanical parameters only. Calculations based on the natural frequency shift revealed that flaps of the posterior cornea were 0.8 times less stiff than flaps from the anterior cornea and cross-linked corneas were 1.6 times stiffer than virgin corneas. Sensitivity analysis showed that natural vibration frequencies of whole globes were nearly independent from corneal thickness and IOP within the physiological range. OCT vibrography is a promising non-invasive technique to measure corneal elasticity without biases from corneal thickness and IOP.
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影响因子：
4.4
作者：
Litwiller, Daniel V.;Lee, Sung J.;Kolipaka, Arunark;Mariappan, Yogesh K.;Glaser, Kevin J.;Pulido, Jose S.;Ehman, Richard L.
通讯作者：
Ehman, Richard L.
影响因子：
2
作者：
von Freyberg, Axel;Sorg, Michael;Goch, Gert
通讯作者：
Goch, Gert
影响因子：
4.4
作者：
Pallikaris, IG;Kymionis, GD;Tsilimbaris, MK
通讯作者：
Tsilimbaris, MK
DOI：
10.1034/j.1600-0420.1998.760313.x
发表时间：
1998-06-01
期刊：
ACTA OPHTHALMOLOGICA SCANDINAVICA
影响因子：
--
作者：
Stodtmeister, R
通讯作者：
Stodtmeister, R
影响因子：
2.4
作者：
Spoerl, Eberhard;Terai, Naim;Pillunat, Lutz E.
通讯作者：
Pillunat, Lutz E.