Silicon photonic crystal nanocavity-coupled waveguides for error-corrected optical biosensing.
Silicon photonic crystal nanocavity-coupled waveguides for error-corrected optical biosensing.
复制标题
硅光子晶体纳米腔耦合的波导用于错误校正的光学生物传感。
DOI：
10.1016/j.bios.2011.03.024
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发表时间：
2011-06-15
影响因子：
12.6
通讯作者：
Fauchet, Philippe M.
中科院分区：
文献类型：
--
作者：
Pal, Sudeshna;Guillermain, Elisa;Sriram, Rashmi;Miller, Benjamin L.;Fauchet, Philippe M.
研究了一种基于光子晶体(PHC)波导型光学生物传感器的无标记纠错传感技术。该生物传感器的检测原理涉及到由于环境折射率的变化而导致耦合到硅PHC波导的纳米腔的共振模式波长的移位。用FDTD理论方法对纳米腔结构的光学特性进行了预测。该器件是使用标准的纳米光刻和反应离子刻蚀技术制造的。实验结果表明，该结构的折射率灵敏度为10−2RIU。通过对人免疫球蛋白分子的检测，测试了该纳米腔传感器的生物传感能力。器件灵敏度为2.3±0.24×105 nm/M，对人免疫球蛋白分子的最低检测下限为1.5fg。此外，实验结果表明，该PHC装置在检测免疫球蛋白方面是特异的，并提供符合朗缪尔行为的浓度依赖的响应。PHC器件显示出作为微尺度无标记纠错传感器的突出潜力，并可能作为超灵敏的多路传输器件具有未来的应用前景。
A photonic crystal (PhC) waveguide based optical biosensor capable of label-free and error-corrected sensing was investigated in this study. The detection principle of the biosensor involved shifts in the resonant mode wavelength of nanocavities coupled to the silicon PhC waveguide due to changes in ambient refractive index. The optical characteristics of the nanocavity structure were predicted by FDTD theoretical methods. The device was fabricated using standard nanolithography and reactive-ion-etching techniques. Experimental results showed that the structure had a refractive index sensitivity of 10−2 RIU. The biosensing capability of the nanocavity sensor was tested by detecting human IgG molecules. The device sensitivity was found to be 2.3 ± 0.24 × 105 nm/M with an achievable lowest detection limit of 1.5 fg for human IgG molecules. Additionally, experimental results demonstrated that the PhC devices were specific in IgG detection and provided concentration-dependent responses consistent with Langmuir behavior. The PhC devices manifest outstanding potential as microscale label-free error-correcting sensors, and may have future utility as ultrasensitive multiplex devices.
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影响因子：
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