A pubertal immune challenge alters the antidepressant-like effects of chronic estradiol treatment in inbred and outbred adult female mice.
A pubertal immune challenge alters the antidepressant-like effects of chronic estradiol treatment in inbred and outbred adult female mice.
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DOI：
10.1016/j.neuroscience.2012.09.047
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发表时间：
2013-09-26
期刊：
影响因子：
3.3
通讯作者：
Blaustein, J. D.
中科院分区：
文献类型：
--
作者：
Ismail, N.;Kumlin, A. M.;Blaustein, J. D.
青春期是一个以大脑重组为特征的时期，有助于对性腺类固醇的神经和行为反应的发展。在青春期单次注射细菌内毒素，脂多糖（LPS），会降低成年后对卵巢激素的性感受性。由于长期雌二醇治疗加重了卵巢切除成年小鼠的抑郁样症状，我们研究了青春期LPS治疗对雌二醇抗抑郁作用的影响。我们假设青春期LPS治疗会降低雌二醇在成年卵巢切除雌性小鼠中的抗抑郁样作用，因为它降低了对卵巢激素的其他行为反应。正如预期的那样，慢性雌二醇治疗减少了抑郁样行为，这是通过两种不同品系的盐水治疗小鼠以及成年期LPS治疗小鼠的不动持续时间来测量的。相反，在青春期用LPS处理的小鼠中，雌二醇显著增加了不动的持续时间。各组之间未发现体重和运动差异，表明抑郁样行为的差异不是由于LPS处理小鼠和对照小鼠之间的体重或运动活动差异所致。这些结果表明，暴露于青春期期间的免疫挑战改变了抑郁样行为的雌二醇的反应。
Puberty is a period characterized by brain reorganization that contributes to the development of neural and behavioral responses to gonadal steroids. A single injection of the bacterial endotoxin, lipopolysaccharide (LPS), during the pubertal period decreases sexual receptivity in response to ovarian hormones in adulthood. Because chronic estradiol treatment alleviates depression-like symptoms in ovariectomized adult mice, we investigated the effect of pubertal LPS treatment on estradiol’s antidepressant effects. We hypothesized that pubertal LPS treatment would decrease the antidepressant-like effect of estradiol in adult ovariectomized female mice, as it decreases other behavioral responses to ovarian hormones. As expected, chronic estradiol treatment decreased depression-like behavior, as measured by the duration of immobility, in saline-treated mice from two different strains, as well as in mice treated with LPS in adulthood. In contrast, in mice treated pubertally with LPS, estradiol strikingly increased the duration of immobility. No difference in body weight and in locomotion was found among the groups, suggesting that the differences in depression-like behavior were not due to differences in body weight or locomotor activity between LPS-treated and control mice. These results suggest that exposure to an immune challenge during the pubertal period alters the responsiveness of depression-like behavior to estradiol.
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影响因子：
2.9
作者：
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通讯作者：
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