Homotypic Cancer Cell Membranes Camouflaged Nanoparticles for Targeting Drug Delivery and Enhanced Chemo-Photothermal Therapy of Glioma.
Homotypic Cancer Cell Membranes Camouflaged Nanoparticles for Targeting Drug Delivery and Enhanced Chemo-Photothermal Therapy of Glioma.
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同型癌细胞膜伪装纳米颗粒用于靶向药物输送和增强胶质瘤化疗光热疗法。
DOI：
10.3390/ph15020157
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发表时间：
2022-01-27
期刊：
影响因子：
--
通讯作者：
Feng S
中科院分区：
文献类型：
--
作者：
Ren Y;Miao C;Tang L;Liu Y;Ni P;Gong Y;Li H;Chen F;Feng S
神经胶质瘤是最致命的脑癌之一，目前尚无有效的治疗方法。化疗是治疗神经胶质瘤的主要方法。然而，耐药性、非靶向性和血脑屏障渗透性差严重抑制了化疗药物的疗效。因此迫切需要改进的治疗方法。在此，通过将石墨烯量子点（GQD）和阿霉素（DOX）封装在同型癌细胞膜（CCM）内，开发了一种多功能仿生纳米平台，用于神经胶质瘤的靶向化学光热治疗。合成了具有稳定荧光和优异的光热转换性能的GQD作为光热治疗剂，并将其与DOX共同封装在CCM中。所制备的纳米平台表现出较高的 DOX 负载效率。细胞膜涂层可防止药物泄漏。在外部激光刺激下，膜可能被破坏，导致 DOX 快速释放。通过利用癌细胞膜的同源靶向性，GQDs/DOX@CCM 可以主动靶向肿瘤细胞，从而显着增强细胞摄取。此外，还观察到 GQDs/DOX@CCM 通过化学光热治疗对癌细胞具有优异的抑制效率。结果表明，这种仿生纳米平台具有有效靶向药物输送和神经胶质瘤协同化学光热治疗的潜力。
Glioma is among the deadliest types of brain cancer, for which there currently is no effective treatment. Chemotherapy is mainstay in the treatment of glioma. However, drug tolerance, non-targeting, and poor blood–brain barrier penetrance severely inhibits the efficacy of chemotherapeutics. An improved treatment method is thus urgently needed. Herein, a multifunctional biomimetic nanoplatform was developed by encapsulating graphene quantum dots (GQDs) and doxorubicin (DOX) inside a homotypic cancer cell membrane (CCM) for targeted chemo-photothermal therapy of glioma. The GQDs with stable fluorescence and a superior light-to-heat conversion property were synthesized as photothermal therapeutic agents and co-encapsulated with DOX in CCM. The as-prepared nanoplatform exhibited a high DOX loading efficiency. The cell membrane coating protected drugs from leakage. Upon an external laser stimuli, the membrane could be destroyed, resulting in rapid DOX release. By taking advantage of the homologous targeting of the cancer cell membrane, the GQDs/DOX@CCM were found to actively target tumor cells, resulting in significantly enhanced cellular uptake. Moreover, a superior suppression efficiency of GQDs/DOX@CCM to cancer cells through chemo-photothermal treatment was also observed. The results suggest that this biomimetic nanoplatform holds potential for efficient targeting of drug delivery and synergistic chemo-photothermal therapy of glioma.
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影响因子：
14
作者：
Fang RH;Jiang Y;Fang JC;Zhang L
通讯作者：
Zhang L
用于靶向递送阿霉素的叶酸共轭介孔二氧化硅功能化氮化硼纳米球
DOI：
10.1016/j.msec.2018.11.063
发表时间：
2019-03-01
影响因子：
7.9
作者：
Feng, Shini;Zhang, Huijie;Gao, Xiao-Dong
通讯作者：
Gao, Xiao-Dong
影响因子：
5.8
作者：
Campbell, Elizabeth;Hasan, Md. Tanvir;Naumov, Anton V.
通讯作者：
Naumov, Anton V.
影响因子：
15
作者：
Lin, Han;Gao, Shanshan;Shi, Jianlin
通讯作者：
Shi, Jianlin
用于肿瘤靶向光动力治疗和缺氧放大生物还原治疗的癌细胞膜涂层仿生平台
影响因子：
14
作者：
Li, Shi-Ying;Cheng, Hong;Zhang, Xian-Zheng
通讯作者：
Zhang, Xian-Zheng