Cell assemblies, sequences and temporal coding in the hippocampus.

Cell assemblies, sequences and temporal coding in the hippocampus.
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DOI:
10.1016/j.conb.2020.03.003
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发表时间:
2020-10
影响因子:
5.7
通讯作者:
Dragoi G
Dragoi G
中科院分区:
医学2区
文献类型:
--
作者:
Dragoi G

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就像社会网络一样,大脑中的神经元是由神经元集合组成的,这些神经元集合限制了单个神经元的作用,同时也丰富了单个神经元活动的时间精度。皮质神经元间协调放电的变化以及神经元间时间和顺序的选择性变化对新信息的编码很重要,这些变化被统称为集合时间编码。在这里,我们回顾了最近关于在线和离线时间编码在啮齿动物海马序列细胞组装中的作用的研究结果,这些细胞组装被认为对记忆编码和巩固以及空间导航很重要。我们认为啮齿类动物海马中的时间编码表现为重放活动的可塑性,主要依赖于睡眠期间单个细胞组装组织微观结构中协调放电的微妙和选择性变化。
Like social networks, neurons in the brain are organized in neuronal ensembles that constrain and at the same time enrich the role and temporal precision of activity of individual neurons. Changes in coordinated firing across cortical neurons as well as selective changes in timing and sequential order across neurons that are important for encoding of novel information have collectively been known as ensemble temporal coding. Here we review recent findings on the role of online and offline temporal coding within sequential cell assemblies from the rodent hippocampus thought be important for memory encoding and consolidation and for spatial navigation. We propose that temporal coding in the rodent hippocampus represented as plasticity in replay activity relies primarily on subtle and selective changes in coordinated firing within the microstructure of individual cell assembly organization during sleep.
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