Organ Weights in Relation to Age and Sex in Cynomolgus Monkeys (Macaca fascicularis).
Organ Weights in Relation to Age and Sex in Cynomolgus Monkeys (Macaca fascicularis).
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DOI：
10.1177/01926233221088283
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发表时间：
2022-07
影响因子：
1.5
通讯作者：
中科院分区：
文献类型：
--
作者：
实验动物研究是人类和动物医学的重要贡献者。目前，食蟹猴（Macaca fascicularis）被广泛用于病理和毒理学研究。本研究的目的是确定不同年龄和性别的束状肌绝对和百分比器官重量的参考值。器官重量是从1997年至2018年维克森林医学院1022只食蟹猴的尸检中获得的。描述了每个器官的绝对权重和百分比权重的分布；使用方差分析对性别和年龄组进行比较。年龄对各性别各器官体重百分比的影响进行了分析。还分析了饮食的影响。该评价显示，所有年龄组的男性体重和绝对器官重量均大于男性；然而，女性的器官占体重的比例在大多数器官中都更高。成熟期间，肾上腺、脑、肺、甲状腺和胸腺器官重量占体重的比例下降，而胰腺、前列腺、睾丸和子宫器官重量占体重的比例上升。食用高脂肪、西式饮食的动物体重低于食用富含碳水化合物的食物的动物。这些信息将为食蟹猴毒理学和病理学的进一步研究提供参考。
Laboratory animal research is an important contributor to both human and animal medicine. Currently, there is extensive use of cynomolgus monkeys (Macaca fascicularis) in pathology and toxicology research. The purpose of this study was to define reference values for absolute and percentage organ weights in M fascicularis of different ages and sex. Organ weights were obtained from necropsies of 1022 cynomolgus monkeys at the Wake Forest School of Medicine from 1997 to 2018. Distributions of absolute and percentage weights for each organ were described; sex and age groups were compared using analysis of variance. Age effects on percentage of body weights for each organ were analyzed within each sex. Diet effects were also analyzed. This evaluation showed that male body weights and absolute organ weights were greater for all age groups; however, female organ to body weight percentages were greater for most organs. Percentage of organ weight to body weight declined for the adrenals, brain, lung, thyroid and thymus during maturation, whereas percentage weight of pancreas, prostate, testes, and uterus increased. Animals consuming a high-fat, Western-type diet had a lower body weight than animals consuming a carbohydrate-rich chow diet. This information will be useful for further toxicology and pathology studies concerning cynomolgus monkeys.
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影响因子：
2.9
作者：
Choi K;Chang J;Lee MJ;Wang S;In K;Galano-Tan WC;Jun S;Cho K;Hwang YH;Kim SJ;Park W
通讯作者：
Park W
DOI：
10.1258/002367770781036481
发表时间：
1970-01-01
期刊：
Laboratory Animals (London)
影响因子：
--
作者：
BOWEN W H;KOCH G
通讯作者：
KOCH G
DOI：
10.1111/j.1440-1754.1992.tb02653.x
发表时间：
1992-06-01
影响因子：
1.7
作者：
MITROPOULOS, G;SCURRY, J;CUSSEN, L
通讯作者：
CUSSEN, L
影响因子：
4.2
作者：
JAYO, MJ;JEROME, CP;WEAVER, DS
通讯作者：
WEAVER, DS
影响因子：
1.8
作者：
Kobayashi, Maiko;Koyama, Takamasa;Sankai, Tadashi
通讯作者：
Sankai, Tadashi