Allergic Rhinitis: A Clinical and Pathophysiological Overview.

Allergic Rhinitis: A Clinical and Pathophysiological Overview.
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DOI:
10.3389/fmed.2022.874114
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发表时间:
2022
影响因子:
3.9
通讯作者:
--
中科院分区:
医学3区
文献类型:
--
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过敏性鼻炎(AR)是一个全球性的健康问题,它影响了全球约4亿人。随着城市化和环境污染的增加,AR的患病率沿着增加,被认为是该疾病的一些主要原因。了解AR的病理生理学对于开发治疗这种经常与其他气道疾病合并的不治之症的新疗法至关重要。因此,在这篇简短的综述中,我们总结了AR的成熟而重要的方面。这些包括流行病学、临床和实验室诊断标准、儿科中的AR、AR的病理生理学、疾病中的Th2应答以及AR患者的药理学和免疫调节疗法。
Allergic rhinitis (AR) represents a global health concern where it affects approximately 400 million people worldwide. The prevalence of AR has increased over the years along with increased urbanization and environmental pollutants thought to be some of the leading causes of the disease. Understanding the pathophysiology of AR is crucial in the development of novel therapies to treat this incurable disease that often comorbids with other airway diseases. Hence in this mini review, we summarize the well-established yet vital aspects of AR. These include the epidemiology, clinical and laboratory diagnostic criteria, AR in pediatrics, pathophysiology of AR, Th2 responses in the disease, as well as pharmacological and immunomodulating therapies for AR patients.
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