Anodal Transcranial Direct Current Stimulation Increases Bilateral Directed Brain Connectivity during Motor-Imagery Based Brain-Computer Interface Control.
Anodal Transcranial Direct Current Stimulation Increases Bilateral Directed Brain Connectivity during Motor-Imagery Based Brain-Computer Interface Control.
复制标题
DOI：
10.3389/fnins.2017.00691
复制
发表时间：
2017
影响因子：
4.3
通讯作者：
He B
中科院分区：
文献类型：
--
作者：
Baxter BS;Edelman BJ;Sohrabpour A;He B
经颅直流电刺激（tDCS）已被证明会影响运动和认知任务的表现和学习时，适用于参与任务的大脑区域。还发现靶向刺激在休息期间改变受刺激半球内的连通性。然而，内源性任务特异性活动和靶向刺激相互作用的连接效应尚不清楚。本研究探讨了在基于一维EEG的感觉运动节律脑机接口（SMR-BCI）任务中，左感觉运动皮层与运动网络连接的并发阳极高清晰度tDCS的后效。在阳极tDCS之后的定向连接说明了额叶和顶叶区域之间的双侧连接发生了改变，并且这些改变以特定于任务的方式发生;在左右想象试验期间，相似的皮层区域之间的连接发生了差异性改变。在右手想象的阳极tDCS后，有一个增加的流出从左运动前皮质（PMC）到多个地区的双边运动网络和增加流入刺激的感觉运动皮层从同侧PMC和对侧感觉运动皮层。在左手想象的阳极tDCS后，有增加的流出从刺激的感觉运动皮层的区域通过运动网络。还发现连接性与总正确试验和命中时间（TTH）正确试验的行为指标之间存在显著相关性，特别是左侧PMC的输入与右手想象力表现下降相关，而从同侧后顶叶皮层（PPC）到中线感觉运动皮层的流量与右手和左手想象力表现改善相关。这些结果表明，tDCS与任务特异性内源性活动相互作用，以改变SMR-BCI期间的定向连接。为了预测和最大限度地发挥tDCS的靶向作用，需要全面检查和了解刺激与内源性活性动态的相互作用。
Transcranial direct current stimulation (tDCS) has been shown to affect motor and cognitive task performance and learning when applied to brain areas involved in the task. Targeted stimulation has also been found to alter connectivity within the stimulated hemisphere during rest. However, the connectivity effect of the interaction of endogenous task specific activity and targeted stimulation is unclear. This study examined the aftereffects of concurrent anodal high-definition tDCS over the left sensorimotor cortex with motor network connectivity during a one-dimensional EEG based sensorimotor rhythm brain-computer interface (SMR-BCI) task. Directed connectivity following anodal tDCS illustrates altered connections bilaterally between frontal and parietal regions, and these alterations occur in a task specific manner; connections between similar cortical regions are altered differentially during left and right imagination trials. During right-hand imagination following anodal tDCS, there was an increase in outflow from the left premotor cortex (PMC) to multiple regions bilaterally in the motor network and increased inflow to the stimulated sensorimotor cortex from the ipsilateral PMC and contralateral sensorimotor cortex. During left-hand imagination following anodal tDCS, there was increased outflow from the stimulated sensorimotor cortex to regions across the motor network. Significant correlations between connectivity and the behavioral measures of total correct trials and time-to-hit (TTH) correct trials were also found, specifically that the input to the left PMC correlated with decreased right hand imagination performance and that flow from the ipsilateral posterior parietal cortex (PPC) to midline sensorimotor cortex correlated with improved performance for both right and left hand imagination. These results indicate that tDCS interacts with task-specific endogenous activity to alter directed connectivity during SMR-BCI. In order to predict and maximize the targeted effect of tDCS, the interaction of stimulation with the dynamics of endogenous activity needs to be examined comprehensively and understood.
登录
查看更多内容
影响因子：
5.7
作者：
Amadi U;Ilie A;Johansen-Berg H;Stagg CJ
通讯作者：
Stagg CJ
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
4.8
作者：
Astolfi, Laura;Cincotti, Febo;Babiloni, Fabio
通讯作者：
Babiloni, Fabio
影响因子：
1.9
作者：
Ding, MZ;Bressler, SL;Liang, HL
通讯作者：
Liang, HL
使用条件格兰杰因果关系评估运动想象和执行过程中运动区域的有效连接
影响因子：
5.7
作者：
Gao, Qing;Duan, Xujun;Chen, Huafu
通讯作者：
Chen, Huafu