Network homeostasis: a matter of coordination.

Network homeostasis: a matter of coordination.
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DOI:
10.1016/j.conb.2009.05.012
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发表时间:
2009-04
影响因子:
5.7
通讯作者:
Fontanini, Alfredo
Fontanini, Alfredo
中科院分区:
医学2区
文献类型:
--
作者:
Maffei, Arianna;Fontanini, Alfredo

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大脑回路在一生中经历着分布式的重排:发育、经验和行为不断地改变突触的强度和网络的连通性。尽管有这些变化,神经元和神经回路需要保持它们的功能稳定性。单个神经元通过调节其突触输入的有效性来维持其在功能工作范围内的自发放电率。但是网络是如何保持稳定的行为的呢?网络稳态是细胞自主机制的结果吗?在本文中,我们将回顾最近的证据,表明网络稳态不仅仅是单个神经元稳态的总和,并且可以通过协调的细胞间相互作用来实现高阶网络稳定性。
Brain circuits undergo distributed rearrangements throughout life: development, experience and behavior constantly modify synaptic strength and network connectivity. Despite these changes, neurons and circuits need to preserve their functional stability. Single neurons maintain their spontaneous firing rate within functional working ranges by regulating the efficacy of their synaptic inputs. But how do networks maintain a stable behavior? Is network homeostasis a consequence of cell autonomous mechanisms? In this article we will review recent evidence showing that network homeostasis is more than the sum of single-neuron homeostasis and that high-order network stability can be achieved by coordinated inter-cellular interactions.
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