Protective effects of higher cognitive reserve for neuropsychological and daily functioning among individuals infected with hepatitis C.
Protective effects of higher cognitive reserve for neuropsychological and daily functioning among individuals infected with hepatitis C.
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DOI：
10.1007/s13365-013-0196-4
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发表时间：
2013-10
影响因子：
3.2
通讯作者：
Huckans, Marilyn
中科院分区：
文献类型：
--
作者：
Sakamoto, Maiko;Woods, Steven Paul;Kolessar, Michael;Kriz, Daniel;Anderson, J. Renee;Olavarria, Hannah;Sasaki, Anna W.;Chang, Michael;Flora, Kenneth D.;Loftis, Jennifer M.;Huckans, Marilyn
更高水平的认知储备（CR）可以防止各种临床疾病中神经损伤的神经心理学表现。然而，CR在丙型肝炎病毒（HCV）感染者神经认知缺陷表达中的作用尚不清楚。根据受教育程度、口头文字阅读和智商得分，将39名HCV感染的参与者分为高CR（n=19）或低CR（n=20）。还纳入了40例人口统计学可比的健康成人（HA）样本。所有参与者完成了神经心理评估组合（NAB），Delis-Kaplan执行功能系统（D-KEFS）和执行功能行为评定量表，成人版（BRIEF-A）。线性回归分析，控制性别，抑郁症和终身物质使用障碍，发现HCV/CR组的语言流畅性，执行功能和日常功能的T分数显着影响，但不是在学习或BRIEF-A。成对比较显示，低CR的HCV组的表现显著低于HCV高CR和HA队列，两者之间没有差异。研究结果表明，较高水平的CR可能是一个保护因素，在神经认知和现实世界的表现，神经损伤通常与HCV感染。
Higher levels of cognitive reserve (CR) can be protective against the neuropsychological manifestation of neural injury across a variety of clinical disorders. However, the role of CR in the expression of neurocognitive deficits among persons infected with the hepatitis C virus (HCV) is not well understood. Thirty-nine HCV-infected participants were classified as having either high (n=19) or low (n=20) CR based on educational attainment, oral word reading, and IQ scores. A sample of 40 demographically comparable healthy adults (HA) was also included. All participants completed the Neuropsychological Assessment Battery (NAB), Delis-Kaplan Executive Function System (D-KEFS), and Behavioral Rating Inventory of Executive Function, Adult Version (BRIEF-A). Linear regression analyses, controlling for gender, depression and lifetime substance use disorders, found significant effects of HCV/CR group on verbal fluency, executive functions, and daily functioning T-scores, but not in learning or the BRIEF-A. Pairwise comparisons revealed that the HCV group with low CR performed significantly below the HCV high CR and HA cohorts, who did not differ from one another. Findings indicate that higher levels of CR may be a protective factor in the neurocognitive and real-world manifestation of neural injury commonly associated with HCV infection.
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影响因子：
3.8
作者：
Forton, DA;Allsop, JA;Taylor-Robinson, SD
通讯作者：
Taylor-Robinson, SD
DOI：
10.1017/s1355617704102130
发表时间：
2004-05-01
影响因子：
2.6
作者：
Heaton, RK;Marcotte, TD;Grant, I
通讯作者：
Grant, I
影响因子：
2.9
作者：
El-Serag, HB
通讯作者：
El-Serag, HB
DOI：
10.1017/s1355617707070877
发表时间：
2007-07-01
影响因子：
2.6
作者：
Bieliauskas, Linas A.;Back-Madruga, Carla;Fontana, Robert J.
通讯作者：
Fontana, Robert J.
DOI：
10.1076/1380-3395(200004)22:2;1-1;ft208
发表时间：
2000-01-01
影响因子：
2.2
作者：
Basso, MR;Bornstein, RA
通讯作者：
Bornstein, RA