Prenatal development of neurons in the human prefrontal cortex: I. A qualitative Golgi study
Prenatal development of neurons in the human prefrontal cortex: I. A qualitative Golgi study
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人类前额皮质神经元的产前发育：I. 定性高尔基体研究
DOI：
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
C. V. van Eden
中科院分区：
文献类型：
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作者：
L. Mrzljak;H. Uylings;I. Kostović;C. V. van Eden
Golgi-Stensaas和快速Golgi染色技术用于研究胎儿、早产儿和妊娠10.5至40周的足月新生儿中发育中的人类前额叶皮层的神经元分化。在10.5周的胎儿中，皮质板上方（边缘区）的水平神经元（Cajal-Retzius神经元）和皮质板下方（原始亚板）的随机定向神经元比未成熟的双极皮质板神经元分化得更多。在妊娠13.5-15周期间，胎儿亚板区可以在皮质板和中间区之间清楚区分。这个亚板区比皮质板含有更多的成熟神经元，尤其是多形神经元。锥体神经元的顶端和基底树突的基本特征在妊娠17至25周之间发育，在丘脑皮质纤维侵入皮质板之前。在此期间，当各种类型的传入纤维驻留在基板区时，基板神经元发生强烈分化。在亚板中可以区分至少五种神经元类型，即，多形性、梭形、多极、正常和倒锥体神经元。传入纤维的向内生长到皮质板之间的26和34周的妊娠与密集的树突分化和棘的外观上的树突的前景层III和V锥体神经元，以及与分化的双花束interneurons在前景颗粒层和层IV。多极非锥体神经元与篮子神经元的树突状特征之间观察到32和34周的妊娠在未来的第五层，他们比双花束神经元分化。亚板区的神经元在妊娠26/27周后继续其树突状分化，并且在足月新生儿中仍然可以观察到。亚板神经元的轴突模式表明它们可能作为中间神经元或投射神经元发挥功能作用。
Golgi‐Stensaas and rapid‐Golgi staining techniques are used to study neuronal differentiation in the developing human prefrontal cortex in fetuses, premature infants, and full‐term newborns from 10.5 to 40 weeks of gestation. Horizontal neurons (Cajal‐Retzius neurons) above the cortical plate (in the marginal zone) and randomly oriented neurons below the cortical plate (in the primordial subplate) are more differentiated than the immature bipolar cortical plate neurons in the 10.5‐week fetus. During 13.5–15 weeks of gestation the fetal subplate zone can be clearly distinguished‐between the cortical plate and the intermediate zone. This subplate zone contains more mature neurons than the cortical plate, especially polymorphous neurons. The basic features of the apical and basal dendrites of pyramidal neurons develop between 17 and 25 weeks of gestation, before the thalamocortical fibres invade the cortical plate. Intensive differentiation of the subplate neurons occurs in this period, when various types of afferent fibres reside in the subplate zone. At least five neuronal types can be distinguished in the subplate, i.e., polymorphous, fusiform, multipolar, normal, and inverted pyramidal neurons. The ingrowth of afferent fibres into the cortical plate between 26 and 34 weeks of gestation coincides with intensive dendritic differentiation and the appearance of spines on dendrites of the prospective layer III and V pyramidal neurons as well as with the differentiation of the double bouquet interneurons in the prospective supragranular layers and layer IV. Multipolar nonpyramidal neurons with the dendritic features of basket neurons are observed between 32 and 34 weeks of gestation in future layer V. They are less differentiated than the double bouquet neurons. The neurons of the subplate zone continue their dendritic differentiation after 26/27 weeks of gestation and are still observed in the full‐term newborn. The axonal pattern of the subplate neurons suggests a possible functional role for them as either interneurons or projection neurons.
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唐氏综合症和阿尔茨海默病中发育调节抗原的重新表达。
DOI：
10.1073/pnas.85.16.6202
发表时间：
1988
影响因子：
11.1
作者：
Wolozin,B;Scicutella,A;Davies,P
通讯作者：
Davies,P
衰老大脑中的树突增殖作为补偿性修复机制。
影响因子：
--
作者：
Coleman,PD;Flood,DG
通讯作者：
Flood,DG
影响因子：
56.9
作者：
COWAN, WM;FAWCETT, JW;STANFIELD, BB
通讯作者：
STANFIELD, BB
DOI：
10.1016/0165-3806(89)90124-7
发表时间：
1989-11
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Nada Zecevic;Jean-Pierre Bourgeois;P. Rakic
通讯作者：
Nada Zecevic;Jean-Pierre Bourgeois;P. Rakic
影响因子：
56.9
作者：
RAKIC, P
通讯作者：
RAKIC, P