Recent evidence for multifactorial biofilm regulation by heme sensor proteins NosP and H-NOX.
Recent evidence for multifactorial biofilm regulation by heme sensor proteins NosP and H-NOX.
复制标题
血红素传感器蛋白NOSP和H-NOX的多因素生物膜调节的最新证据。
作者：
血红素通过作为血红素气体/氧化还原传感器的辅助因子或与血红素反应蛋白反向结合参与信号转导。细菌通过H-NOX家族和新发现的血红素传感器蛋白NosP对低浓度的一氧化氮（NO）做出反应，调节生物膜等群体行为。作为基于血红素的NO传感器，NosP与H-NOX具有相似的功能；两者都调节双组分系统和/或循环二gmp代谢酶，在群体感应和生物膜调节等过程中发挥作用。有趣的是，除了它在NO信号传导中的作用，最近的研究表明NosP也可能感知不稳定的血红素。在这篇综述中，我们简要总结了细菌中h - nox依赖的NO信号传导，然后重点介绍了nosp介导的NO信号传导和不稳定血红素传感的最新进展。
Heme is involved in signal transduction by either acting as a cofactor of heme-based gas/redox sensors or binding reversely to heme-responsive proteins. Bacteria respond to low concentrations of nitric oxide (NO) to modulate group behaviors such as biofilms through the well-characterized H-NOX family and the newly discovered heme sensor protein NosP. NosP shares functional similarities with H-NOX as a heme-based NO sensor; both regulate two-component systems and/or cyclic-di-GMP metabolizing enzymes, playing roles in processes such as quorum sensing and biofilm regulation. Interestingly, aside from its role in NO signaling, recent studies suggest that NosP may also sense labile heme. In this Highlight Review, we briefly summarize H-NOX-dependent NO signaling in bacteria, then focus on recent advances in NosP-mediated NO signaling and labile heme sensing.
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影响因子：
3.6
作者：
Bellini D;Caly DL;McCarthy Y;Bumann M;An SQ;Dow JM;Ryan RP;Walsh MA
通讯作者：
Walsh MA
影响因子：
5.3
作者：
Bhagirath, Anjali Y.;Pydi, Sai P.;Duan, Kangmin
通讯作者：
Duan, Kangmin
影响因子：
2.8
作者：
Burrowes, E;Baysse, C;O'Gara, F
通讯作者：
O'Gara, F
影响因子：
3.6
作者：
Carlson HK;Vance RE;Marletta MA
通讯作者：
Marletta MA
影响因子：
56.9
作者：
COLE, RP
通讯作者：
COLE, RP