Levels of hexachlorobenzene (HCB) in breast milk in relation to birth weight in a Norwegian cohort.
Levels of hexachlorobenzene (HCB) in breast milk in relation to birth weight in a Norwegian cohort.
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DOI：
10.1016/j.envres.2009.04.001
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发表时间：
2009-07
影响因子：
8.3
通讯作者：
Magnus, Per
中科院分区：
文献类型：
--
作者：
Eggesbo, Merete;Stigum, Hein;Longnecker, Matthew P.;Polder, Anuschka;Aldrin, Magne;Basso, Olga;Thomsen, Cathrine;Skaare, Janneche Utne;Becher, Georg;Magnus, Per
六氯苯（HCB）是一种普遍存在的环境污染物，在实验研究中，即使是低剂量，也会导致卵巢原始生殖细胞的破坏。然而，暴露于背景水平的人类对其生殖毒性的潜在影响尚未得到充分评估。在这里，我们研究了母亲HCB水平与其婴儿出生体重之间的关系。在2003-2006年挪威母乳研究（HUMIS）中，对一部分妇女的牛奶样本进行了HCB测量。从队列中随机选择300名受试者，从所有小于胎龄（SGA）儿童中随机选择26名受试者。通过问卷调查和医疗出生登记处获得了更多信息。总体而言，HCB与出生体重（调整后的b= - 90 g/ 8 μg/kg乳脂，95% CI为- 275至8）和SGA (OR为1.8,95% CI为0.9-3.7 / 8 μg/kg乳脂（第10和第90百分位之间的差异）相关。然而，在分层之后，这种关联只存在于吸烟者中。过去或现在吸烟者的出生体重：b= - 282， CI为- 467至- 98；从不吸烟者：b=0.5， CI为- 149 ~ 150，相互作用的p值为0.01。在头围、冠跟长度和SGA方面也观察到类似的结果。我们发现，在过去和现在的吸烟者中，HCB与胎儿生长受损标志物之间存在中度关联。这一发现可能不是因果关系，是由于与六氯环己烷生长和分解有关的潜在遗传变异，或由于暴露源中共存的未测量毒物的混淆。然而，它也可能是由接触六氯甲烷引起的。
Hexachlorobenzene (HCB) is a ubiquitous environmental contaminant that, even at low doses, causes destruction of ovarian primordial germ cells in experimental studies. However, its potential for reproductive toxicity in humans exposed to background levels has not been fully evaluated. Here we examined the association between maternal levels of HCB and their infants’ birth weight. HCB was measured in milk samples from a subset of women in the Norwegian Human Milk Study (HUMIS), 2003–2006. 300 subjects were randomly chosen from the cohort and 26 from all small for gestational age (SGA) children. Additional information was obtained through questionnaires and the Medical Birth Registry. Overall, HCB was associated with birth weight (adjusted b=−90 g per eight μg/kg milk fat, 95 % CI −275 to 8) and with SGA (OR 1.8, 95 % CI 0.9–3.7 per eight μg/kg milk fat (difference between the 10th and the 90th percentile)). After stratification, however, the association was present only among smokers. For birth weight for past or current smokers: b=−282, CI −467 to −98; for never smokers: b=0.5, CI −149 to 150, p-value for interaction: 0.01. Similar results were observed for head circumference, crown-heel length, and SGA. We saw a moderate association between HCB and markers of impaired fetal growth among past and current smokers. This finding may be non-causal and due to underlying genetic variants tied to both growth and breakdown of HCB or to confounding by unmeasured toxicants that coexist in exposure sources. It may, however, also result from HCB exposure.
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影响因子：
3.6
作者：
Ribas-Fitó, N;Sala, M;Sunyer, J
通讯作者：
Sunyer, J
影响因子：
8.8
作者：
Bailey, RE
通讯作者：
Bailey, RE
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2.5
作者：
Jauniaux, Eric;Burton, Graham J.
通讯作者：
Burton, Graham J.
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作者：
Gladen, BC;Shkiryak-Nyzhnyk, ZA;Little, RE
通讯作者：
Little, RE
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3.8
作者：
ENDRESEN, EH;HELSING, E
通讯作者：
HELSING, E