Age- and gender-associated differences in electrical impedance values of skeletal muscle.
Age- and gender-associated differences in electrical impedance values of skeletal muscle.
复制标题
骨骼肌电阻抗值的年龄和性别相关差异。
DOI：
10.1088/0967-3334/34/12/1611
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发表时间：
2013-12
影响因子：
3.2
通讯作者：
Rutkove SB
中科院分区：
文献类型：
--
作者：
Kortman HG;Wilder SC;Geisbush TR;Narayanaswami P;Rutkove SB
骨骼肌的电阻抗测量可能对与年龄相关的肌肉健康下降敏感。为了进一步评估这一概念，我们使用手持式阵列对38名19-50岁的个体和41名60-85岁的个体进行了电阻抗肌造影（EIM）。个体测量了7个上肢或7个下肢肌肉。50 kHz电抗、电阻和相位被用作主要结果变量。虽然两组的相位值相似，但老年人下肢的电抗和电阻值均低于年轻人（电抗为−23 ± 6%，p = 0.001，电阻为−27 ± 7%，p = 0.005），而上肢值的变化无显著差异（电抗为−9 ± 5%，p = 0.096;电阻为+5 ± 9%，p = 0.55）。当分别分析性别时，很明显，下肢值的这种降低在男性中最明显，在女性中不太一致。这些发现表明，年龄和性别相关的肌肉状况的差异是使用EIM检测。这些容易获得的参数的标准功能，影像学和肌肉减少症的病理标志物的关系值得进一步研究。
Electrical impedance measurements of skeletal muscle may be sensitive to age-associated declines in muscle health. In an effort to evaluate this concept further, we performed electrical impedance myography (EIM) using a handheld array on 38 individuals aged 19–50 years and 41 individuals aged 60–85 years. Individuals either had 7 upper extremity or 7 lower extremity muscles measured. The 50 kHz reactance, resistance and phase were used as the major outcome variables. Although the phase values were similar in both groups, both reactance and resistance values were lower in the lower extremities of the older individuals as compared to the younger (−23 ± 6%, p = 0.001 for reactance and −27 ± 7%, p = 0.005 for resistance), whereas changes in upper extremity values were not significantly different (−9 ± 5%, p = 0.096 for reactance and +5 ± 9%, p = 0.55 for resistance). When analyzing the genders separately, it became clear that this reduction in lower extremity values was most pronounced in men and less consistently present in women. These findings suggest that age- and gender-associated differences in muscle condition are detectable using EIM. The relationship of these easily obtained parameters to standard functional, imaging, and pathological markers of sarcopenia deserves further study.
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影响因子：
4.3
作者：
Tarulli, Andrew W.;Duggal, Naven;Esper, Gregory J.;Garmirian, Lindsay P.;Fogerson, Patricia M.;Lin, Connie H.;Rutkove, Seward B.
通讯作者：
Rutkove, Seward B.
影响因子：
3.2
作者：
Aaron, Ronald;Esper, Gregory J.;Rutkove, Seward B.
通讯作者：
Rutkove, Seward B.
影响因子：
3.4
作者：
Rutkove, Seward B.
通讯作者：
Rutkove, Seward B.
影响因子：
3.3
作者：
Pillard, Fabien;Laoudj-Chenivesse, Dalila;Rolland, Yves
通讯作者：
Rolland, Yves
DOI：
10.3109/17482968.2012.688837
发表时间：
2012-09
期刊：
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
影响因子：
--
作者：
Rutkove SB;Caress JB;Cartwright MS;Burns TM;Warder J;David WS;Goyal N;Maragakis NJ;Clawson L;Benatar M;Usher S;Sharma KR;Gautam S;Narayanaswami P;Raynor EM;Watson ML;Shefner JM
通讯作者：
Shefner JM