Association of Pioglitazone with Increased Risk of Prostate Cancer and Pancreatic Cancer: A Functional Network Study.
Association of Pioglitazone with Increased Risk of Prostate Cancer and Pancreatic Cancer: A Functional Network Study.
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吡格列酮与前列腺癌和胰腺癌风险增加的关联：功能网络研究
DOI：
10.1007/s13300-018-0509-y
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Sun J
中科院分区：
文献类型：
--
作者：
Wen W;Wu P;Gong J;Zhao M;Zhang Z;Chen R;Chen H;Sun J
抗糖尿病药物吡格列酮是否会增加癌症风险的问题已经争论了一段时间。最近的研究表明，使用吡格列酮可增加前列腺癌和胰腺癌的风险。然而，目前还不清楚吡格列酮是否是这些cancer.MethodsIn这项研究中，我们的目的是探索吡格列酮和基因相关的直接目标，通过查询开放平台，以构建一个生物学功能网络，然后进一步评估吡格列酮与前列腺癌和胰腺癌的关系。我们确定了吡格列酮的4个直接靶点和50个吡格列酮相关基因，然后使用STRING和WebGestalt选择这些基因进行KEGG通路分析。该分析产生了前25个KEGG通路，其中4个通路与位点特异性癌症相关，包括前列腺癌和胰腺癌。最后，使用cBioPortal的基因组研究表明，基因组改变的两个基因组相关的前列腺癌和胰腺癌的途径，分别与加速的cancerogenication.ConclusionsPioglitazone可能是一个因果风险因素，前列腺癌和胰腺癌，所以这种药物应谨慎使用。目前的研究还表明，使用生物功能网络分析，有效地探索药物相互作用和药物安全性。
IntroductionThe question of whether pioglitazone, an antidiabetic drug, increases the risk of cancer has been debated for some time. Recent studies have shown that pioglitazone use can increase the risk of prostate cancer as well as pancreatic cancer. However, it is unclear whether pioglitazone is a causal risk factor for these cancers.MethodsIn this study, we aimed to explore the direct targets of pioglitazone and genes associated with this drug by querying open platforms in order to construct a biological function network, and then to further evaluate the relationships of pioglitazone with prostate cancer and pancreatic cancer.ResultsWe first tested our hypothesis using DrugBank and STRING. We identified four direct targets of pioglitazone and 50 pioglitazone-associated genes, which were then selected for KEGG pathway analysis using STRING and WebGestalt. This analysis generated the top 25 KEGG pathways, among which four pathways were related to site-specific cancers, including prostate cancer and pancreatic cancer. Finally, a genomic study using cBioPortal indicated that genomic alterations of two gene sets related to the prostate cancer and pancreatic cancer pathways, respectively, are associated with the acceleration of carcinogenesis.ConclusionsPioglitazone is likely to be a causal risk factor for prostate cancer and pancreatic cancer, so this drug should be used with caution. The present research also demonstrates the use of biological function network analysis to effectively explore drug interactions and drug safety profiles.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
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82.9
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168.9
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影响因子：
5.1
作者：
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Webgestalt 2017：一种更全面，强大，灵活和交互式基因集富集分析工具包。
影响因子：
14.9
作者：
Wang J;Vasaikar S;Shi Z;Greer M;Zhang B
通讯作者：
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