Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder.
Impaired discriminative fear-conditioning resulting from elevated fear responding to learned safety cues among individuals with panic disorder.
复制标题
DOI：
10.1016/j.brat.2008.10.017
复制
发表时间：
2009-02
影响因子：
4.1
通讯作者：
Grillon C
中科院分区：
文献类型：
--
作者：
Lissek S;Rabin SJ;McDowell DJ;Dvir S;Bradford DE;Geraci M;Pine DS;Grillon C
经典的恐惧条件反射是惊恐障碍（PD）的许多病因学解释的核心，但很少有基于实验室的PD条件反射研究。一个条件反射的角度提出关联学习缺陷的特点是缺乏安全学习的PD患者。目前的研究PD评估收购和保留的歧视厌恶条件反射恐惧增强惊吓范式。选择这种范式是因为它具有独立评估安全性和安全性学习的特定能力，以表征PD患者中每种学习类型中的假定异常。尽管在保留时没有发现恐惧增强惊吓的组间差异，但习得结果表明PD患者的辨别学习受损，这是通过对习得的安全和危险线索的条件性惊吓增强措施来衡量的。重要的是，这种歧视赤字是由增强惊吓增强学习安全提示，而不是异常反应的危险线索。与这一发现相一致，PD患者相对于健康个体在安全提示的存在下报告了更高的危险结果预期，但在暴露于危险提示期间报告了相等的危险预期。这些结果将PD与受损的辨别学习联系起来，反映了对学习到的安全提示的恐惧感升高。
Classical fear-conditioning is central to many etiologic accounts of panic disorder (PD), but few lab-based conditioning studies in PD have been conducted. One conditioning perspective proposes associative-learning deficits characterized by deficient safety learning among PD patients. The current study of PD assesses acquisition and retention of discriminative aversive conditioning using a fear-potentiated startle paradigm. This paradigm was chosen for its specific capacity to independently assess safety- and danger-learning in the service of characterizing putative anomalies in each type of learning among those with PD. Though no group difference in fear-potentiated startle was found at retention, acquisition results demonstrate impaired discrimination learning among PD patients as indexed by measures of conditioned startle-potentiation to learned safety and danger cues. Importantly, this discrimination deficit was driven by enhanced startle potentiation to the learned safety-cue rather than aberrant reactivity to the danger cue. Consistent with this finding, PD patients relative to healthy individuals reported higher expectancies of dangerous outcomes in the presence of the safety cue, but equal danger expectancies during exposure to the danger cue. Such results link PD to impaired discrimination learning, reflecting elevated fear responding to learned safety-cues.
登录
查看更多内容
影响因子：
4.6
作者：
Grillon, C;Morgan, CA
通讯作者：
Morgan, CA
影响因子：
17.7
作者：
Grillon, Christian;Lissek, Shmuel;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
3.5
作者：
OREILLY, RC;MCCLELLAND, JL
通讯作者：
MCCLELLAND, JL
影响因子：
17.7
作者：
Grillon, Christian;Lissek, Shmuel;Pine, Daniel S.
通讯作者：
Pine, Daniel S.
影响因子：
4.6
作者：
Orr, SP;Metzger, LJ;Pitman, RK
通讯作者：
Pitman, RK